ATN-224

ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1, IC50s = 2.91 and 3.51 µM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).Formal Name: 2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate. CAS Number: 649749-10-0. Synonyms: Bis-Choline Tetrathiomolybdate. Molecular Formula: C5H14NO . 1/2MoS4. Formula Weight: 432.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 242, 315, 468 nm. SMILES: C[N+](C)(C)CCO.C[N+](C)(C)CCO.S=[Mo-2](=S)(=S)=S. InChi Code: InChI=1S/2C5H14NO.Mo.4S/c2*1-6(2,3)4-5-7,,,,,/h2*7H,4-5H2,1-3H3,,,,,/q2*+1,-2,,,,. InChi Key: XTDZSQBNDXNMJY-UHFFFAOYSA-N.