ARV-766
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A PROTAC that drives androgen receptor degradation (DC50 = <1 nM), inhibits tumor growth in... more
Product information "ARV-766"
A PROTAC that drives androgen receptor degradation (DC50 = <1 nM), inhibits tumor growth in various LNCaP and VCaP prostate cancer mouse xenograft models, including an enzalutamide-insensitive, non-castrated VCaP model. Formulation: A solid. InChI: InChI=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)58-5)50-39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-21-51)32-11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28,36,42-43H,14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42-,43-/m0/s1. InChIKey: RDPPBRKNBBXPNZ-FMPIRMQTSA-N. SMILES: CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(F)=C5)C(N[C@H]6CCC(NC6=O)=O)=O)CC4)C=C2)=O)[C@H]1OC7=CC(OC)=C(C=C7)C#N
| Keywords: | Luxdegalutamide, 4-[4-[[1-[4-[[[trans-3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-N-[(3S)-2,6-dioxo-3-piperidinyl]-2-fluoro-benzamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 41985 |
Properties
| Application: | Androgen receptor degradation driving PROTAC |
| Immunogen: | 807.95 |
| MW: | 807.95 D |
| Formula: | C45H54FN7O6 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2750830-09-0| Matching products |
| KEGG ID : | K08557 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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