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Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Cay-20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.Formal Name: 4-[4-(phenylmethyl)phenyl]-2-thiazolamine. CAS Number: 68729-05-5. Molecular Formula: C16H16N2S. Formula Weight: 268.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.1 mg/ml, DMSO: 10 mg/ml, Ethanol: 1mg/ml. lambdamax: 236, 285, 344 nm. SMILES: NC(N1)=SC=C1C(C=C2)=CC=C2CC3=CC=CC=C3. InChi Code: InChI=1S/C16H16N2S/c17-16-18-15(11-19-16)14-8-6-13(7-9-14)10-12-4-2-1-3-5-12/h1-9,11,18-19H,10,17H2. InChi Key: CEXYUVBVAHGQJI-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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