Apraclonidine (hydrochloride)

Apraclonidine is an alpha2-adrenergic receptor (alpha2-AR) agonist and structural analog of clonidine (Cay-15949). It binds to alpha2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to alpha2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively). It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively). Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.Formal Name: 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine, monohydrochloride. CAS Number: 73218-79-8. Synonyms: AL0 2145, ALO 2145. Molecular Formula: C9H10Cl2N4 . HCl. Formula Weight: 281.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: ClC1=C(NC2=NCCN2)C(Cl)=CC(N)=C1.Cl. InChi Code: InChI=1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9,/h3-4H,1-2,12H2,(H2,13,14,15),1H. InChi Key: OTQYGBJVDRBCHC-UHFFFAOYSA-N.