API-1
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent,... more
Product information "API-1"
Description: API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, beta-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . Target: Akt. Smiles: NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c2c1=O. References: Ren H , Koo J , Guan B , et al. The E3 ubiquitin ligases beta-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis[J]. Molecular Cancer, 2013, 12(1):146-146.
| Keywords: | NSC177223 |
| Supplier: | TargetMol |
| Supplier-Nr: | T8969 |
Properties
| Application: | AKT inhibitor |
| MW: | 337.29 D |
| Formula: | C13H15N5O6 |
Database Information
| CAS : | 36707-00-3| Matching products |
| KEGG ID : | K04456 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301 |
| P Phrases: | P264, P270, P301+310, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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