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ANR 94 is an adenosine A2A receptor antagonist (Ki = 0.046 µM). It is selective for the adenosine A2A receptor over adenosine A1, -A2B, and -A3 receptors (Kis = 2.4, >30, and 21 µM, respectively). ANR 94 (5 mg/kg) reduces the number of parkinsonian-like tremors induced by tacrine (Cay70240) in rats. It decreases neurodegeneration and neuroinflammation in the substantia nigra pars compacta in a mouse model of MPTP-induced Parkinson's disease when administered at a dose of 0.5 mg/kg. ANR 94 (5 mg/kg) increases alcohol intake but not water or food intake in alcohol-preferring rats. SMILES CCOC1=NC2=C(N)N=CN=C2N1CC InChi Code InChI=1S/C9H13N5O/c1-3-14-8-6(7(10)11-5-12-8)13-9(14)15-4-2/h5H,3-4H2,1-2H3,(H2,10,11,12) InChi Key QUGDTMONBLMLLD-UHFFFAOYSA-N
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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