Ampiroxicam

Ampiroxicam is a prodrug of piroxicam (Cay-13368), a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits COX-1 and COX-2 (IC50s = 1.57 and 1.69 µM, respectively). Ampiroxicam is converted to piroxicam at a rate of 100, 90, 70, and 50% in humans, rats, dogs, and monkeys, respectively.Formal Name: carbonic acid, ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester. CAS Number: 99464-64-9. Synonyms: CP 65,703. Molecular Formula: C20H21N3O7S. Formula Weight: 447.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 10 mg/ml. lambdamax: 315 nm. SMILES: O=S1(C2=CC=CC=C2C(OC(C)OC(OCC)=O)=C(C(NC3=CC=CC=N3)=O)N1C)=O. InChi Code: InChI=1S/C20H21N3O7S/c1-4-28-20(25)30-13(2)29-18-14-9-5-6-10-15(14)31(26,27)23(3)17(18)19(24)22-16-11-7-8-12-21-16/h5-13H,4H2,1-3H3,(H,21,22,24). InChi Key: LSNWBKACGXCGAJ-UHFFFAOYSA-N.