Amorfrutin A

Solid. Soluble in DMSO, ethanol or methanol. Insoluble in water. Antidiabetic agent, Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta, Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity, Shows potent PPARgamma-dependent anti-inflammatory activity, Potent NF-?B activation inhibitor by the suppression of I?B? degradation, p65 nuclear translocation and DNA-binding activity, Antimicrobial agent.