Aminopterin

Aminopterin is a synthetic folic acid (Cay-20515) derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate (Cay-13960) is now more commonly used due to a more favorable therapeutic index. Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.Formal Name: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid. CAS Number: 54-62-6. Synonyms: 4-amino Folic Acid, 4-amino PGA, APGA, NSC 739. Molecular Formula: C19H20N8O5. Formula Weight: 440.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF:, DMSO:, Ethanol: Slightly, Water: Partly. SMILES: NC1=NC2=NC=C(CNC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)N=C2C(N)=N1. InChi Code: InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1. InChi Key: TVZGACDUOSZQKY-LBPRGKRZSA-N.