Amifostine thiol (hydrochloride)

Amifostine thiol is a radioprotective agent and an active metabolite of amifostine (Cay-14398). It is formed from amifostine by plasma membrane-bound alkaline phosphatase. Amifostine thiol scavenges ABTS (Cay-27317) radicals in a cell-free assay. It prevents single- and double-stranded DNA breaks induced by gamma-radiation, as well as inhibits gamma-radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in V79-B310H lung fibroblast cells when used at a concentration of 4 mM. Amifostine thiol also reduces cis-DDP-induced mutations at the HGPRT locus in V79-B310H cells. It increases survival, reduces the loss of bone marrow progenitor cells, and inhibits decreases in intestinal collagen thickness and crypt and Paneth cell density in mice exposed to total body gamma-irradiation when administered at a dose of 500 mg/kg prior to irradiation.Formal Name: 2-[(3-aminopropyl)amino]-ethanethiol, dihydrochloride. CAS Number: 14653-77-1. Synonyms: WR 1065. Molecular Formula: C5H14N2S . 2HCl. Formula Weight: 207.2. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: NCCCNCCS.Cl.Cl. InChi Code: InChI=1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8,,/h7-8H,1-6H2,2*1H. InChi Key: XDRLRDHLCIFZIW-UHFFFAOYSA-N.