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Description: AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 values of 5 nM, 4 nM, and 1 nM, respectively. It exhibits over 10-fold selectivity for Aurora kinases compared to p38alpha, Tyk2, JNK2, Met, and Tie2. [Phase 1]. Target: p38 MAPK, Tyrosine Kinases, Aurora Kinase. Smiles: Cc1csc(c1)-c1nnc(Nc2ccc(Oc3ncccc3-c3ccnc(N)n3)cc2)c2ccccc12. References: Payton M, et al, Cancer Res, 2010, 70(23), 9846-19854.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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