AM2394

AM2394 is an activator of glucokinase with an EC50 value of 60 nM in an enzyme assay in the presence of glucose. Oral administration of AM2394 (3-30 mg/kg) decreases plasma glucose levels in an oral glucose tolerance test in an ob/ob mouse model of diabetes.Formal Name: N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-urea. CAS Number: 1442684-77-6. Molecular Formula: C22H25N5O4. Formula Weight: 423.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml. lambdamax: 269 nm. SMILES: CC1=CC(OC2=CC(NC(NC)=O)=NC=C2C3=CC=C(OCC(C)(O)C)N=C3)=CN=C1. InChi Code: InChI=1S/C22H25N5O4/c1-14-7-16(11-24-9-14)31-18-8-19(27-21(28)23-4)25-12-17(18)15-5-6-20(26-10-15)30-13-22(2,3)29/h5-12,29H,13H2,1-4H3,(H2,23,25,27,28). InChi Key: QUISANLDBDCMPD-UHFFFAOYSA-N.