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A 20S proteasome inhibitor (IC50 = ~1 µM), induces the accumulation of ubiquitinated proteins in HCT116 colon cancer cells at 1 µM, sensitizes HCT116 p53+/+ and HCT116 p53-/- cells to ionizing radiation-induced cytotoxicity in an additive and synergistic manner, respectively, decreases the viability of macrophages isolated from patients with rheumatoid arthritis (IC50 = 0.88 µM). Formulation: A solid. InChI: InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3. InChIKey: SRPIKXGUPAKTIZ-UHFFFAOYSA-N. SMILES: OB(C1=CC=C(C=C(CN(CC2=CC(C=C3)=CC=C3B(O)O)C)C2=O)C=C1)O
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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