alpha-Zearalanol

alpha-Zearalanol is an active metabolite formed by reduction of alpha-zearalenol (Cay-16549), an estrogen receptor antagonist. alpha-Zearalanol inhibits [3H]estradiol binding to estrogen receptors (ERs) on calf uterus in a dose-dependent manner. Dietary alpha-zearalanol (10 mg/kg per day) increases endometrial thickness, bone mineral density, and serum levels of alkaline phosphatase in ovariectomized rats. It also decreases sperm count and motility and serum levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in male mice.Formal Name: (3S,7R)-3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one. CAS Number: 26538-44-3. Synonyms: MK-188, (-)-alpha-Zearalanol. Molecular Formula: C18H26O5. Formula Weight: 322.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. lambdamax: 219, 266, 304 nm. SMILES: OC1=C(C(O[C@@H](C)CCC[C@H](O)CCCCC2)=O)C2=CC(O)=C1. InChi Code: InChI=1S/C18H26O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,14,19-21H,2-9H2,1H3/t12-,14+/m0/s1. InChi Key: DWTTZBARDOXEAM-GXTWGEPZSA-N.