Alizarin

Alizarin is a small molecule inhibitor of cytochrome P450 isoforms CYP1A1, CYP1A2, and CYP1B1 (IC50s = 6.2, 10, and 2.7 µM, respectively). Alizarin acts as an antioxidant against iodophenol-derived phenoxyl radicals, superoxide anion radicals, and lipid peroxidation in rat liver microsomes. It also reduces hepatic content of thiobarbituric acid-reactive substances and serum levels of alanine aminotransferase in poisoned rats. Alizarin is also used as a red dye to stain bacteria, human adipose-derived stem cells, multipotent adult progenitor cells, skin, hair, and keratin fibers.Formal Name: 1,2-dihydroxy-9,10-anthracenedione. CAS Number: 72-48-0. Synonyms: CI-58000, NSC 7212. Molecular Formula: C14H8O4. Formula Weight: 240.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: Slightly soluble. lambdamax: 248, 433 nm. SMILES: O=C1C2=C(C(O)=C(O)C=C2)C(C3=C1C=CC=C3)=O. InChi Code: InChI=1S/C14H8O4/c15-10-6-5-9-11(14(10)18)13(17)8-4-2-1-3-7(8)12(9)16/h1-6,15,18H. InChi Key: RGCKGOZRHPZPFP-UHFFFAOYSA-N. Origin: Synthetic.