Ajmalicine

Ajmalicine is an terpenoid indole alkaloid that has been found in R. serpentina. It is an alpha1-adrenergic receptor antagonist, reducing the phenylephrine-induced pressor response in pithed rats when administered at doses ranging from 1 to 4 mg/kg. It also binds to alpha2A-, alpha2B-, alpha2C-, and alpha2D-adrenergic receptors (Kis = 8.2, 14.5, 5, and 289 nM, respectively). Ajmalicine, in combination with almitrine, improves hemodynamic and metabolic parameters following transient cerebral ischemia in dogs.Formal Name: (19alpha)-16,17-didehydro-19-methyl-oxayohimban-16-carboxylic acid, methyl ester. CAS Number: 483-04-5. Synonyms: (-)-Ajmalicine, NSC 72133, NSC 95087, Raubasine. Molecular Formula: C21H24N2O3. Formula Weight: 352.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: soluble. lambdamax: 227 nm. SMILES: O=C(OC)C1=CO[C@@H](C)[C@]2([H])[C@]1([H])C[C@]3([H])N(CCC4=C3NC5=CC=CC=C45)C2. InChi Code: InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1. InChi Key: GRTOGORTSDXSFK-XJTZBENFSA-N. Origin: Natural/Source unknown.