Agrimol B

Agrimol B is a polyphenol that has been found in A. pilosa with adipogenesis inhibitory and anticancer activities. It induces nuclear translocation of sirtuin 1 (SIRT1) and reduces expression of peroxisome proliferator-activated receptor gamma (PPARgamma), C/EBPalpha, and fatty acid synthase (FASN) in 3T3-L1 adipocytes when used at a concentration of 10 µM. Agrimol B reduces lipid droplet accumulation in 3T3-L1 adipocytes (IC50 = 3.35 µM). It is cytotoxic to PC3 prostate and A549 lung cancer cells in vitro and reduces tumor volume in a PC3 mouse xenograft model when administered at a dose of 10 mg/kg.Formal Name: (2S)-1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone. CAS Number: 55576-66-4. Molecular Formula: C37H46O12. Formula Weight: 682.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. lambdamax: 230, 288 nm. SMILES: OC(C(CC1=C(C(C(CCC)=O)=C(C(C)=C1O)OC)O)=C(C(C([C@@H](C)CC)=O)=C2O)O)=C2CC3=C(C(C(CCC)=O)=C(C(C)=C3O)OC)O. InChi Code: InChI=1S/C37H46O12/c1-9-12-23(38)25-32(44)19(29(41)17(5)36(25)48-7)14-21-31(43)22(35(47)27(34(21)46)28(40)16(4)11-3)15-20-30(42)18(6)37(49-8)26(33(20)45)24(39)13-10-2/h16,41-47H,9-15H2,1-8H3/t16-/m0/s1. InChi Key: BVLHMPZMQVWDGX-INIZCTEOSA-N. Origin: Plant/Agrimonia pilosa.