AGPS-IN-2i

Description: AGPS-IN-2i is a potent and high-affinity inhibitor of alkylglycerol phosphate synthase that controls ether lipid utilization and metabolism in cells, reduces ether lipid levels and cell migration, and promotes proliferation and motility of cancer cells. AGPS-IN-2i had an inhibitory effect on cancer cell proliferation. Target: MMP. Smiles: C(NC(CC(C)C1=C(F)C=CC=C1F)=O)C=2C=C3C(=CC2)NC(=O)N3. References: Stazi G, et al. Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. Eur J Med Chem. 2019 , 163:722-735.