Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010243-1 1 mg -

6 - 10 business days*

Cay10010243-5 5 mg -

6 - 10 business days*

Cay10010243-10 10 mg -

6 - 10 business days*

Cay10010243-50 50 mg -

6 - 10 business days*

The HER2/Neu proto-oncogene is a member of the epidermal growth factor receptor (EGFR) family of... more
Product information "AG-825"
The HER2/Neu proto-oncogene is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTK) which includes EGFR, HER2/Neu, HER3 and HER4. Overexpression of HER2/Neu occurs in 25-30% of human breast and ovarian cancer. AG-825 is a selective ATP-competitive inhibitor of the tyrosine kinase activity of HER2/Neu. In cell-free assays, AG-825 inhibits Her2/Neu, EGFR, and PDGFR autophosphorylation with IC50 values of 0.35, 19, and 40 µM, respectively. However, in select whole cells, the high concentration of ATP prevents inhibition of kinase activity by AG-825. Concentrations of 50 µM AG-825, however, consistently inhibit Her2/Neu signalling and promote killing of human LNCaP, C4, and C4-2 prostate cancer cells. Formal Name: 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide. CAS Number: 149092-50-2. Synonyms: Tyrphostin AG-825. Molecular Formula: C19H15N3O3S2. Formula Weight: 397.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO: PBS (pH 7.2)(1:3): 0.1 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 225, 361 nm. SMILES: N#C/C(=C\c1cc(CSc2nc3ccccc3s2)c(O)c(OC)c1)/C(=O)N. InChi Code: InChI=1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+. InChi Key: KXDONFLNGBQLTN-WUXMJOGZSA-N. Origin: Synthetic.
Keywords: Tyrphostin AG-825, 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
Supplier: Cayman Chemical
Supplier-Nr: 10010243


Application: HER-2/neu inhibitor
MW: 397.5 D
Formula: C19H15N3O3S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 149092-50-2| Find alternatives
KEGG ID : K05083 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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