Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010568-1 1 mg -

6 - 10 business days*

Cay10010568-5 5 mg -

6 - 10 business days*

Cay10010568-10 10 mg -

6 - 10 business days*

Cay10010568-25 25 mg -

6 - 10 business days*

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases... more
Product information "AG-370"
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 µM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 µM). Formal Name: 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile. CAS Number: 134036-53-6. Synonyms: NSC 651712. Molecular Formula: C15H9N5. Formula Weight: 259.3. Purity: >95% (cis/trans mixture). Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml. lambdamax: 260, 367 nm. SMILES: c12c(ccc(c1)/C=C(\C(=C(\C#N)C#N)N)C#N)[nH]cc2. InChi Code: InChI=1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,20H,19H2/b12-6+. InChi Key: CMMDWEJTQUTCKG-WUXMJOGZSA-N.
Keywords: NSC 651712, 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile
Supplier: Cayman Chemical
Supplier-Nr: 10010568


Application: PDGF receptor kinase inhibitor
MW: 259.3 D
Formula: C15H9N5
Purity: >95% (cis/trans mixture)
Format: Crystalline Solid

Database Information

CAS : 134036-53-6| Find alternatives
KEGG ID : K04363 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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