ADU-S100

ADU-S100 is a cyclic dinucleotide STING agonist. It induces IFN-beta-dependent reporter activity in HEK293T cells expressing human STING, the human STING variants STING HAQ, STING REF, STING AQ, STING Q, or mouse STING when used at a concentration of 10 µM. Intratumoral administration of ADU-S100 (50 µg/tumor per day for three days) reduces tumor growth in wild-type, but not in Sting1-/-, mice in a B16/F10 murine melanoma model. It decreases primary and secondary tumor volume in a 4T1 murine breast cancer model of tumor rechallenge when intratumorally administered. Unilateral intratumoral administration of ADU-S100 reduces tumor volumes in a bilateral CT26 murine colorectal cancer model. It increases tumor infiltration of natural killer (NK) cells, CD4+ T cells, and CD8+ T cells, as well as increases immune cell-induced tumor necrosis, in a GL261 murine glioma model when intratumorally administered at a dose of 50 µg/tumor.Formal Name: [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'->5')-adenosine cyclic nucleotide, disodium salt. CAS Number: 1638750-95-4. Synonyms: MIW815, ML RR S2-CDA. Molecular Formula: C20H22N10O10P2S2 . 2Na. Formula Weight: 734.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, Water: Sparingly Soluble: 1-10 mg/ml. SMILES: O[C@@H]([C@H](N1C=NC2=C(N)N=CN=C21)O3)[C@@](O[P@@]4([S-])=O)([H])[C@@]3([H])CO[P@](O[C@@]5([H])[C@H](N6C=NC7=C(N)N=CN=C76)O[C@@]([H])([C@]5(O)[H])CO4)([S-])=O.[Na+].[Na+]. InChi Code: InChI=1S/C20H24N10O10P2S2.2Na/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(32)13-8(38-19)2-36-42(34,44)40-14-11(31)7(1-35-41(33,43)39-13)37-20(14)30-6-28-10-16(22)24-4-26-18(10)30,,/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,43)(H,34,44)(H2,21,23,25)(H2,22,24,26),,/q,2*+1/p-2/t7-,8-,11-,12-,13-,14-,19-,20-,41-,42-,,/m1../s1. InChi Key: GDWOOOCBNOMMTL-ITQXCAEYSA-L.