Adenosine-5'-O-(2-thiodiphosphate) (sodium salt)

Adenosine-5'-O-(2-thiodiphosphate) is an agonist of purinergic P2Y receptors. It increases glucose-stimulated insulin release in isolated rat pancreas when used at concentrations ranging from 49.5 to 495 nM. Adenosine-5'-O-(2-thiodiphosphate) (1.5 µM) induces vasodilation in isolated rat pancreas and relaxation in isolated rat aortic rings precontracted by serotonin (5-HT, Cay-14332) with an EC50 value of 0.09 µM. It increases insulin secretion and reduces elevated glucose levels in fasted dogs when administered at a dose of 0.1 mg/kg.Formal Name: 5'-adenylic acid, anhydride with phosphorothioic acid, trisodium salt. Synonyms: ADP-beta-S. Molecular Formula: C10H12N5O9P2S . 3Na. Formula Weight: 509.2. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O[C@@H]1[C@@H](COP(OP([S-])([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H15N5O9P2S.3Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27,,,/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27),,,/q,3*+1/p-3/t4-,6-,7-,10-,,,/m1.../s1. InChi Key: CBQAEBOGKWYQRX-MSQVLRTGSA-K.