31 products were found matching "K04269"!

Adenosine 5'-(gamma-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11). It has been used to identify kinase substrates, has been implemented as a reagent in the synthesis of DNA N-acetylglucosamine analogs,...

UTP is a nucleotide and dual agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors). It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = >10,000 nM). UTP stimulates proliferation of PANC-1...

Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties. It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites. It acts as...

Description: Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film stability and visual function, as a topical treatment of dry eye disease. Target: P2Y Receptor. Smiles:...

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It...

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases,...

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases,...

LUF6000 is a positive allosteric modulator of adenosine A3 receptors. It reduces dissociation of the agonist I-AB-MECA from A3 receptors and increases the efficacy, but not potency, of 2-Cl-IB-MECA-induced inhibition of forskolin-stimulated cAMP accumulation by 45% in CHO cells expressing the human receptor when...

Protein function: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. [The UniProt Consortium]

Diquafosol is an agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays). It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM). Ocular application of diquafosol (0.1 and 1% w/v) induces the release of mucin-like glycoproteins from...

Adenosine-5'-O-(2-thiodiphosphate) is an agonist of purinergic P2Y receptors. It increases glucose-stimulated insulin release in isolated rat pancreas when used at concentrations ranging from 49.5 to 495 nM. Adenosine-5'-O-(2-thiodiphosphate) (1.5 µM) induces vasodilation in isolated rat pancreas and relaxation in...

Uridine-5'-O-(3-thiotriphosphate) (UTP-gamma-S) is a hydrolysis-resistant derivative of UTP (Cay-9003530) an agonist of the purinergic P2Y2 receptor. It induces inositol phosphate formation in 1321N1 astrocytoma cells expressing the human P2Y2 receptor (EC50 = 240 nM) and chloride secretion in primary nasal...