ACY-957 (hydrochloride)

ACY-957 is an inhibitor of histone deacetylase 1 (HDAC1) and HDAC2 (IC50s = 7 and 18 nM, respectively). It is selective for HDAC1 and HDAC2 over HDAC3 (IC50 = 1,300 nM) and does not inhibit HDAC4-9 at concentrations up to 20 µM. ACY-957 (1 µM) induces expression of HBG, the gene encoding gamma-globin, in peripheral blood mononuclear cells (PBMCs) isolated from patients with sickle cell disease. SMILES NC1=C(NC(C2=CC(C=C3)=C(C=C2)N=C3N4CCNCC4)=O)C=C(C5=CC=CS5)C=C1.Cl InChi Code InChI=1S/C24H23N5OS.ClH/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29,/h1-8,13-15,26H,9-12,25H2,(H,28,30),1H InChi Key AACRPMFRIVUUMC-UHFFFAOYSA-N