ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone (ACTH, Cay-24257), a peptide hormone found in the brain that is involved in the biological stress response. An acetylated form of ACTH (1-13), alpha-melanocyte stimulating hormone (alpha-MSH), is formed in the intermediate lobe of the pituitary gland by cleavage of ACTH (1-39), as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells. ACTH (1-13) is an agonist of melanocortin receptor 3 (MC3R) and MC4R, inducing cAMP production in vitro with EC50 values of 0.18 and 19 nM, respectively, which is similar in potency to that of alpha-MSH. It induces differentiation of melanocytes when used at concentrations ranging from 0.001 to 1,000 nM. ACTH (1-13) (40 and 400 pmol, i.c.v.) decreases food intake in broiler chicks.Formal Name: alpha1-13-corticotropin, trifluoroacetate salt. Synonyms: SYSMEHFRWGKPV-OH. Molecular Formula: C75H106N20O19S . XCF3COOH. Formula Weight: 1623.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: .2mg/mL, DMSO: 10mg/mL, Ethanol: slightly soluble, PBS (pH 7.2): 10mg/mL. lambdamax: 278 nm. SMILES: [H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)=O)CCSC)=O)=O)CC6=CC=C(O)C=C6)=O.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C75H106N20O19S.C2HF3O2/c1-41(2)62(74(113)114)94-72(111)59-19-12-29-95(59)73(112)53(17-9-10-27-76)85-60(99)37-83-64(103)56(33-44-35-82-49-16-8-7-15-47(44)49)91-65(104)50(18-11-28-81-75(78)79)86-68(107)55(31-42-13-5-4-6-14-42)90-70(109)57(34-45-36-80-40-84-45)92-66(105)51(24-25-61(100)101)87-67(106)52(26-30-115-3)88-71(110)58(39-97)93-69(108)54(89-63(102)48(77)38-96)32-43-20-22-46(98)23-21-43,3-2(4,5)1(6)7/h4-8,13-16,20-23,35-36,40-41,48,50-59,62,82,96-98H,9-12,17-19,24-34,37-39,76-77H2,1-3H3,(H,80,84)(H,83,103)(H,85,99)(H,86,107)(H,87,106)(H,88,110)(H,89,102)(H,90,109)(H,91,104)(H,92,105)(H,93,108)(H,94,111)(H,100,101)(H,113,114)(H4,78,79,81),(H,6,7)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,/m0./s1. InChi Key: FFIXASBSGNFZNW-JMIITERTSA-N.