30 products were found matching "K04201"!

PG-106 is a cyclic peptidomimetic antagonist of melanocortin receptor 3 (MC3R, IC50 = 210 nM). It is selective for MC3R over MC4R and MC5R at 10 µM. InChI:...

Recombinant CHO-K1 cells stably overexpress human melanocortin 3 receptor (MC3R) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

[D-Trp8]-gamma-MSH is a melanocortin receptor 3 (MC3R) agonist and an analog of gamma-melanocyte-stimulating hormone (gamma-MSH). It selectively induces cAMP accumulation in cells expressing MC3R over cells expressing MC4R or MC5R (EC50s = 0.33, 100, and 82 nM, respectively, for the human receptors). In vivo,...

Protein function: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Melanocortin 3 Receptor Protein function: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of...

ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone (ACTH, Cay-24257), a peptide hormone found in the brain that is involved in the biological stress response. An acetylated form of ACTH (1-13), alpha-melanocyte stimulating hormone (alpha-MSH), is formed in the intermediate lobe of the pituitary gland...

AP1189 is a biased agonist of melanocortin receptor 1 (MC1R) and MC3R. It induces ERK1 and ERK2 phosphorylation but not canonical cAMP production in HEK293 cells expressing human MC1R or MC3R when used at concentrations ranging from 10 pM to 1 mM. AP1189 (0.1-10 nM) reduces zymosan-induced IL-1beta, IL-6, and...

Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen Affinity Purified. Target Name: MC3R. Antigen Species: Human

Description: AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors. Target: Melanocortin Receptor. Smiles: O=[N+](C1=CC=CC=C1N2C(/C=C/C=N/NC(N)=N)=CC=C2)[O-].CC(O)=O. References: Montero-Melendez T, et al. Biased agonism as a novel strategy to harness the proresolving properties of...

TCMCB07 is a peptide antagonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (IC50s = 19.5, 0.59, 13.58, and 8.07 nM, respectively, for the human receptors). It is also an antagonist of dog MC1R, MC3R, MC4R, and MC5R receptors (IC50s = 53.64, 1.46, 7.14, and 11.22 nM, respectively). TCMCB07 (10 mg/kg)...

Tag: C-Human Fc tag. This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene...

Protein function: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock...