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ACBI1 is a proteolysis-targeting chimera (PROTAC) composed of a ligand for BRM, also known as SMARCA2, BRG1, also known as SMARCA4, and polybromo-1D (PBRM1), which are components of switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes, conjugated to a von Hippel-Lindau (VHL) E3 ligase ligand. It induces degradation of BRM, BRG1, and PBRM1 with 50% degradation concentration (DC50) values of 6, 11, and 32 nM, respectively, in MV4-11 acute myeloid leukemia (AML) cells. ACBI1 decreases the proliferation of MV4-11 cells (IC50 = 28 nM) but is inactive against NCI H1703 non-small cell lung cancer (NSCLC) cells, which do not express BRM or BRG1. It prevents exhaustion of isolated human CD8+ T cells when used at concentrations of 50 and 100 nM.Formal Name: (2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide. CAS Number: 2375564-55-7. Molecular Formula: C49H58FN9O7S. Formula Weight: 936.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 266 nm. SMILES: NC1=C(N2CCN(CC2)CC3=CC=C(C=C3)OCCOC4=C(C=CC(C5=C(N=CS5)C)=C4)CNC([C@H]6N(C[C@@H](C6)O)C([C@H](C(C)(C)C)NC(C7(CC7)F)=O)=O)=O)C=C(C8=C(C=CC=C8)O)N=N1. InChi Code: InChI=1S/C49H58FN9O7S/c1-30-42(67-29-53-30)32-11-12-33(26-52-45(62)39-24-34(60)28-59(39)46(63)43(48(2,3)4)54-47(64)49(50)15-16-49)41(23-32)66-22-21-65-35-13-9-31(10-14-35)27-57-17-19-58(20-18-57)38-25-37(55-56-44(38)51)36-7-5-6-8-40(36)61/h5-14,23,25,29,34,39,43,60-61H,15-22,24,26-28H2,1-4H3,(H2,51,56)(H,52,62)(H,54,64)/t34-,39+,43-/m1/s1. InChi Key: IVARZBJJMMUJHI-SQKKEFIPSA-N.
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