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Acarbose is an oligosaccharide and inhibitor of alpha-glucosidases (IC50s = 0.16 and 2.9 µM for maltase and sucrase, respectively). It also activates phosphorylase kinase in a cell-free assay when used at a concentration of 250 µM. Acarbose (40 mg/kg in the diet) decreases urine levels of glucose and glycosylated hemoglobin, as well as glomerular mesangial thickening in a db/db mouse model of diabetic nephropathy. It reduces sucrose-induced increases in infarct size as a percentage of the area at risk and serum malondialdehyde (MDA) levels in a mouse model of cardiac ischemia-reperfusion injury induced by coronary artery ligation when administered at a dose of 10 mg/kg.Formal Name: O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-alpha-D-glucopyranosyl-(1->4)-O-alpha-D-glucopyranosyl-(1->4)-D-glucose. CAS Number: 56180-94-0. Synonyms: BAY-g 5421. Molecular Formula: C25H43NO18. Formula Weight: 645.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 20 mg/mL, PBS (pH 7.2): 10 mg/mL. SMILES: O=C[C@H](O)[C@@H](O)[C@]([C@H](O)CO)([H])O[C@H]([C@H](O)[C@H]1O)O[C@H](CO)[C@@]1([H])O[C@@H](O[C@@H]2C)[C@H](O)[C@@H](O)[C@@H]2N[C@@]3([H])C=C(CO)[C@@H](O)[C@H](O)[C@H]3O. InChi Code: InChI=1S/C25H43NO18/c1-7-13(26-9-2-8(3-27)14(33)18(37)15(9)34)17(36)20(39)24(41-7)44-23-12(6-30)42-25(21(40)19(23)38)43-22(11(32)5-29)16(35)10(31)4-28/h2,4,7,9-27,29-40H,3,5-6H2,1H3/t7-,9+,10+,11-,12-,13-,14-,15+,16-,17+,18+,19-,20-,21-,22-,23-,24-,2. InChi Key: CEMXHAPUFJOOSV-XGWNLRGSSA-N. Origin: Plant/Glycyrrhiza glabra.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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