Ac-VDVAD-pNA (trifluoroacetate salt)

Ac-VDVAD-pNA is a colorimetric substrate for caspase-2. Caspase-2 binds to and cleaves the Val-Asp-Val-Ala-Asp (VDVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-2 activity. Ac-VDVAD-pNA can also be cleaved, with lower efficiency, by caspase-3 and -7.Formal Name: N-acetyl-L-valyl-L-alpha-aspartyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-alpha-asparagine, trifluoroacetate salt. Synonyms: Ac-Val-Asp-Val-Ala-Asp-pNA, Caspase-2 Chromogenic Substrate, acetyl-Val-Asp-Val-Ala-Asp-p-nitroanilide, acetyl-VDVAD-p-nitroanilide. Molecular Formula: C29H41N7O12 . XCF3COOH. Formula Weight: 679.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Formic Acid: 1 mg/ml. SMILES: O=C(O)C[C@H](NC([C@H](C)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC(C)=O)C(C)C)=O)=O)C(C)C)=O)=O)C(NC(C=C1)=CC=C1[N+]([O-])=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C29H41N7O12.C2HF3O2/c1-13(2)23(31-16(6)37)29(46)34-20(12-22(40)41)27(44)35-24(14(3)4)28(45)30-15(5)25(42)33-19(11-21(38)39)26(43)32-17-7-9-18(10-8-17)36(47)48,3-2(4,5)1(6)7/h7-10,13-15,19-20,23-24H,11-12H2,1-6H3,(H,30,45)(H,31,37)(H,32,43)(H,33,42)(H,34,46)(H,35,44)(H,38,39)(H,40,41),(H,6,7)/t15-,19-,20-,23-,24-,/m0./s1. InChi Key: GBBBMAYPADJDNR-RJOXADQZSA-N.