ABT-751

ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on beta-tubulin (Ki = 3.3 µM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 µg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.Formal Name: N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-benzenesulfonamide. CAS Number: 141430-65-1. Molecular Formula: C18H17N3O4S. Formula Weight: 371.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 244, 280 nm. SMILES: COC1=CC=C(S(NC2=CC=CN=C2NC3=CC=C(O)C=C3)(=O)=O)C=C1. InChi Code: InChI=1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20). InChi Key: URCVCIZFVQDVPM-UHFFFAOYSA-N.