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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay44289-1 | 1 mg | - |
6 - 10 business days* |
364.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ABBV-467 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, Ki = 642, >376, >247, and >402 nM,... more
Product information "ABBV-467"
ABBV-467 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, Ki = <0. nM). It is selective for Mcl-1 over Bcl-2, Bcl-xL, Bcl-W, and Bcl-2-A1 (Kis = >642, >376, >247, and >402 nM, respectively). ABBV-467 reduces the viability of AMO1, NCI H929, and MV4-11 myeloma cells (EC50s = 0. 0. and 3. nM, respectively). In vivo, ABBV-467 (3. 6. and 12. mg/kg) reduces tumor growth in an AMO1 mouse xenograft model. InChI: InChI=1S/C53H51Cl2FN6O9S/c1-30-43-31(2)47(55)48(46(30)54)70-39(24-62-18-16-61(3)17-19-62)27-68-38-12-13-41(69-25-36-14-15-57-50(60-36)33-6-10-37(11-7-33)67-28-40-26-65-20-21-66-40)34(22-38)23-42(53(63)64)71-51-45-44(43)49(72-52(45)59-29-58-51)32-4-8-35(56)9-5-32/h4-15,22,29,39-40,42H,16-21,23-28H2,1-3H3,(H,63,64)/t39-,40-,42-/m1/s1 InChIKey: BOMNURVTAHAEBQ-KWIIHVIGSA-N SMILES: CC(C(C1=C(C2=CC=C(C=C2)F)SC3=NC=NC(O[C@H](CC4=C(C=CC(OC[C@H](O5)CN6CCN(CC6)C)=C4)OCC7=NC(C8=CC=C(OC[C@@H]9OCCOC9)C=C8)=NC=C7)C(O)=O)=C13)=C%10C)=C(Cl)C5=C%10Cl
| Keywords: | (7R,16R)-19,23-dichloro-10-[[2-[4-[(2R)-1,4-dioxan-2-ylmethoxy]phenyl]-4-pyrimidinyl]methoxy]-1-(4-fluorophenyl)-7,8,15,16-tetrahydro-20,22-dimethyl-16-[(4-methyl-1-piperazinyl)methyl]-18,21-etheno-9,13-metheno-13H-6,14,17-trioxa-2-thia-3,5-diazacyclonona |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 44289 |
Properties
| Application: | Mcl-1 inhibitor |
| MW: | 1037.98 D |
| Formula: | C53H51Cl2FN6O9S |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 2287186-66-5| Matching products |
| KEGG ID : | K02539 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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