A1480LS

A1480LS is a peripherally biased inhibitor of diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta (IC50s = 6 and 4 nM, respectively, in human brain membrane homogenates). It reduces levels of the DAGL-derived endocannabinoid 2-arachidonoyl glycerol (2-AG) in peripheral tissue but not in the brain in mice when administered at 20 mg/kg. A1480LS (20 mg/kg, p.o.) reduces mechanical allodynia in rat models of inflammatory pain and chemotherapy-induced neuropathy without inducing CNS adverse effects in the Irwin primary observation test.. SMILES: O=C(N1N=C2C=CC(C3=CC=CC=C3)=CC2=C1)N4CCN(C[C@@H]4CC5=CC=CC=C5)C6=NC(C(F)(F)F)=CN=C6. InChi Code: InChI=1S/C30H25F3N6O/c31-30(32,33)27-17-34-18-28(35-27)37-13-14-38(25(20-37)15-21-7-3-1-4-8-21)29(40)39-19-24-16-23(11-12-26(24)36-39)22-9-5-2-6-10-22/h1-12,16-19,25H,13-15,20H2/t25-/m0/s1. InChi Key: LULPTIBVONZWPH-VWLOTQADSA-N