27 products were found matching "K13806"!

In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. KT109 is a selective inhibitor of DAGLbeta with an IC50 value of 42 nM. It demonstrates ~60-fold selectivity for DAGLbeta over...

In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLalpha (IC50 = 690 nM). It demonstrates much weaker inhibition towards human...

RHC-80267 is an inhibitor of diacylglycerol lipase (DAGL, IC50 = 4 µM for the canine platelet enzyme). It also inhibits the serine hydrolases KIAA1363, fatty acid amide hydrolase (FAAH), BAT5, phospholipase A2 (PLA2), hormone-sensitive lipase (HSL), and acetylcholinesterase (AChE) by greater than 60% when used at a...

In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. LEI-106 is a potent in vitro inhibitor of sn-1 DAGLalpha (IC50 = 18 nM). It blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural...

KT172 is a non-selective inhibitor of diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol (Cay-10008650) in HEK293T cell membranes expressing recombinant DAGLalpha or DAGLbeta (IC50s = 140 and 60 nM, respectively). KT172 also inhibits...

Protein function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. [The UniProt Consortium]

Protein function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Diacylglycerol lipase alpha Protein function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for...

(S)-KT109 is the (S) isomer of the diacylglycerol lipase beta (DAGLbeta) inhibitor KT109 (Cay-18933). (S)-KT109 is a less potent inhibitor of DAGLbeta (IC50 = 39.81 nM), DAGLalpha-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and alpha/beta-hydrolase domain-containing protein 6...

(R)-KT109 is the (R) isomer of the diacylglycerol lipase beta (DAGLbeta) inhibitor KT109 (Cay-18933). (R)-KT109 is an inhibitor of DAGLbeta (IC50 = 0.79 nM) and of DAGLalpha-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (Cay-10008650, IC50 = 25.12 nM). It also inhibits alpha/beta-hydrolase...

Protein function: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2- arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain...

Protein function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid...