A-484954
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A-484954 is an ATP-competitive inhibitor of eukaryotic elongation factor-2 kinase (eEF-2K, IC50 =... more
Product information "A-484954"
A-484954 is an ATP-competitive inhibitor of eukaryotic elongation factor-2 kinase (eEF-2K, IC50 = 420 nM). It reduces eEF-2K autophosphorylation in PC3, HeLa, H460, H1299, and MDA-MB-231 cancer cells when used at a concentration of 75 µM.Formal Name: 7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide. CAS Number: 142557-61-7. Molecular Formula: C13H15N5O3. Formula Weight: 289.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 229, 287, 333 nm. SMILES: O=C1N(CC)C(C(C=C(C(N)=O)C(N)=N2)=C2N1C3CC3)=O. InChi Code: InChI=1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19). InChi Key: HWODCHXORCTEGU-UHFFFAOYSA-N.
| Keywords: | 7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 28279 |
Properties
| Application: | ATP-competitive eukaryotic elongation factor-2 kinase (eEF-2K) inhibitor |
| MW: | 289.3 D |
| Formula: | C13H15N5O3 |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 142557-61-7| Matching products |
| KEGG ID : | K08292 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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