A-1210477

A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1, Ki = 0.43 nM and IC50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (Kis > 0.66 µM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1). It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.Formal Name: 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid. CAS Number: 1668553-26-1. Molecular Formula: C46H55N7O7S. Formula Weight: 850.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly, DMSO: slightly, Ethanol: slightly. SMILES: CN(C)S(N1CCN(C2=CC=C(OCC3=C(C4=CC=CC5=C4N(CCN6CCOCC6)C(C(O)=O)=C5CCCOC7=C(C=CC=C8)C8=CC=C7)C(C)=NN3C)C=C2)CC1)(=O)=O. InChi Code: InChI=1S/C46H55N7O7S/c1-33-43(41(49(4)47-33)32-60-36-19-17-35(18-20-36)51-22-24-52(25-23-51)61(56,57)48(2)3)40-14-8-13-38-39(15-9-29-59-42-16-7-11-34-10-5-6-12-37(34)42)45(46(54)55)53(44(38)40)26-21-50-27-30-58-31-28-50/h5-8,10-14,16-20H,9,15,21-32H2.