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A-1210477
Item number: TGM-T2632-100mg
Description: A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM). Target: Apoptosis, BCL. Smiles: C(CN1CCOCC1)N2C3=C(C=CC=C3C(CCCOC=4C5=C(C=CC4)C=CC=C5)=C2C(O)=O)C6=C(COC7=CC=C(C=C7)N8CCN(S(N(C)C)(=O)=O)CC8)N(C)N=C6C. References: Leverson JD, et al. Cell Death Dis. 2015,...
| CAS | 1668553-26-1 |
| MW: | 850.04 D |
From 34.00€
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A-1210477
Item number: Cay21113-5
A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1, Ki = 0.43 nM and IC50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (Kis > 0.66 µM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1). It has been shown to disrupt the interaction between Mcl-1...
| Keywords: | 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethy... |
| Application: | Mcl-1 inhibitor |
| CAS | 1668553-26-1 |
| MW: | 850 D |
From 40.00€
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