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Etedesiran
Item number: TGM-T82438-50mg
Description: Etedesiran acts as an inhibitor of Myotonin-protein kinase (MT-PK, MDPK, or DMPK) [1]. Target: Others
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Erzotabart
Item number: TGM-T82440-10mg
Description: Erzotabart, an IgG1-kappa monoclonal antibody targeting CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) in Homo sapiens, exhibits antineoplastic activity [1]. Target: CD38
From 233.00€
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Epothilone D1
Item number: TGM-T82453-50mg
Description: Epothilone D1, a naturally derived isolate, exhibits cytotoxic effects on mouse fibroblasts. Target: Others
| CAS | 252917-35-4 |
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Epoetin zeta
Item number: TGM-T82454-50mg
Description: Epoetin zeta, a derivative of the endogenous protein erythropoietin, functions as an erythropoiesis-stimulating agent. It is utilized to investigate symptomatic anemia associated with renal disorders, referred to as symptomatic renal anemia [1]. Target: Others
| Application: | Targets erythropoietin receptor (EPOR) |
| CAS | 604802-70-2 |
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Epoetin beta
Item number: TGM-T82455-50mg
Description: Epoetin beta (rhEPO), a recombinant erythropoietin, is crucial for sustaining erythropoiesis and is utilized in anemia research [1]. Target: Others
| Keywords: | EPOCH, Genetical recombination, rhEPO |
| Application: | Targets erythropoietin receptor (EPOR) |
| CAS | 122312-54-3 |
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Encelimab
Item number: TGM-T82471-10mg
Description: Encelimab, an anti-LAG3 monoclonal antibody, prevents the interaction between LAG-3 and MHC class II molecules, thereby facilitating the activation of T-cells and promoting an enhanced anti-tumor immune response. Encelimab demonstrates efficacy in preclinical models, as it has been observed to reduce...
From 392.00€
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Empasiprubart
Item number: TGM-T82474-10mg
Description: Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of...
| Keywords: | ARGX-117 |
From 233.00€
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Elebsiran sodium
Item number: TGM-T82481-50mg
Description: Elebsiran sodium is an siRNA targeting hepatitis B and D virus infections [1]. Target: Others
| Keywords: | VIR-2218 sodium |
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eIF4E-IN-6
Item number: TGM-T82489-50mg
Description: eIF4E-IN-6 (Compound 4b), a GMP analog, is designed to inhibit the eIF4E protein's ability to bind to cap mRNA. It demonstrates cytotoxic effects on Caco-2, HepG-2, and MCF-7 cell lines with IC50 values of 31, 27, and 21 µM, respectively [1]. Target: Others
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EGFR-IN-90
Item number: TGM-T82491-50mg
Description: EGFR-IN-90 (compound 34), an orally active EGFR inhibitor, demonstrates potent activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and effectively inhibits the proliferation of the H1975-TM cell line carrying EGFRL858R/T790M/C797S mutations with an IC50 of 0.05 µM. Additionally, EGFR-IN-90...
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EGFR/HER2/DHFR-IN-3
Item number: TGM-T82492-50mg
Description: EGFR/HER2/DHFR-IN-3 (compound 4c) is an efficacious dual inhibitor of EGFR/HER2 with IC50 values of 0.138 µM for EGFR and 0.092 µM for HER2, respectively, and also inhibits DHFR with an IC50 of 0.193 µM. It induces cell cycle arrest in the S phase and triggers apoptosis in MCF7 breast cancer cells [1]....
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EGFR/HER2/DHFR-IN-2
Item number: TGM-T82493-50mg
Description: EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 µM, respectively, and exhibits anticancer activity, displaying IC50 values of 9.14, 7.33, 14.18, 24.87, 20.07, and 6.16 µM in Hep G2, HeLa, HEp-2, HCT 116, PC-3, and MCF7 cancer cell...
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