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PEG2000-C-DMG
Item number: TGM-T74405-2mg
Description: PEG2000-C-DMG, a pegylated lipid, facilitates the creation of Onpattro, a hepatically targeted investigational RNAi therapeutic that effectively decreases the synthesis of both mutant and wild-type transthyretin by precisely targeting the 3' untranslated region of transthyretin mRNA [1] [2]. Target: Others
| MW: | 2610.29 D |
69.00€
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EVT-401
Item number: TGM-T74409-50mg
Description: EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1]. Target: Others
| MW: | 436.4 D |
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PROTAC AR-V7 degrader-1
Item number: TGM-T74410-50mg
Description: PROTAC AR-V7 degrader-1 (Compound 6) is an orally bioavailable, potent, and selective degrader targeting the androgen receptor (AR) variant V7, achieving degradation with a DC50 of 0.32 µM by directing the VHL E3 ligase to the AR DNA-binding domain (DBD). It demonstrates efficacy in the 22Rv1 cell line...
| CAS | 2767440-24-2 |
| MW: | 789.02 D |
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dTAGV-1-NEG TFA
Item number: TGM-T74412-50mg
Description: dTAGV-1-NEG TFA, a diastereomer, serves as the heterobifunctional negative control for dTAGV-1. It acts specifically as an FKBP12 F36V-selective degrader [1]. Target: Others
| MW: | 1361.56 D |
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(S)-Osanetant
Item number: TGM-T74413-50mg
Description: (S)-Osanetant, the S-enantiomer of Osanetant (SR142801), is a selective NK3 receptor antagonist known for its anxiolytic- and antidepressant-like effects. It is currently under investigation for potential use in treating schizophrenia [1]. Target: Others
| CAS | 182621-58-5 |
| MW: | 606.62 D |
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Imlunestrant tosylate
Item number: TGM-T74415-50mg
Description: Imlunestrant tosylate (LY-3484356) is a potent, orally active selective estrogen receptor degrader (SERD) with purely antagonistic properties, effectively inhibiting estrogen receptor (ER)-dependent gene transcription and cell growth. This compound is applicable in research on ER-positive (ER+) advanced...
| Application: | Antineoplastic |
| CAS | 2408840-41-3 |
| MW: | 696.71 D |
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Mulnitorsen
Item number: TGM-T74419-50mg
Description: Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1]. Target: Others
| CAS | 2576358-63-7 |
| MW: | 5704.66 D |
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BRD7-IN-3
Item number: TGM-T77680-50mg
Description: BRD7-IN-3 (compound 1-78) is a dual inhibitor of bromodomain-containing proteins BRD7 and BRD9, with half-maximal inhibitory concentrations (IC50s) of 1.6 µM for BRD7 and 2.7 µM for BRD9, respectively [1]. Target: Epigenetic Reader Domain
| MW: | 294.35 D |
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Obeversen
Item number: TGM-T74420-50mg
Description: Obeversen is a DGAT-2 synthesis reducer [1]. Target: Others
| CAS | 2304711-30-4 |
| MW: | 8606.36 D |
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Xalnesiran sodium
Item number: TGM-T74423-50mg
Description: Xalnesiran (sodium) is an siRNA designed for the treatment of chronic hepatitis B (HBV). Target: Others
| CAS | 2538784-49-3 |
| MW: | 22262.12 D |
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Biotinylated-JQ1
Item number: TGM-T74428-50mg
Description: Biotinylated-JQ1 (Biotin-JQ1), a biotinylated derivative of JQ1, selectively binds to the BRD4 bromodomain with high affinity. It effectively inhibits the proliferation of MM1.S multiple myeloma cells, demonstrating an EC50 of 0.4 µM [1]. Target: Others
| CAS | 1635437-52-3 |
| MW: | 829.47 D |
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SJ10542
Item number: TGM-T74429-2mg
Description: SJ10542, a phenyl glutarimide (PG)-PROTAC, demonstrates potent and selective activity against JAK2/3 by exhibiting DC50 values of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. It employs a PG ligand for cereblon (CRBN) recruitment [1]. Target: PROTACs
| CAS | 2789678-92-6 |
| MW: | 818.95 D |
1,355.00€
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