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Thalidomide-NH-PEG7
Item number: TGM-T18814-100mg
Description: Thalidomide-NH-PEG7 is a synthesized conjugate of an E3 ligase ligand and linker, intended for use in antibody-drug conjugates (ADCs). It can be attached to a protein ligand via a linker to form PROTAC iRucaparib-AP6, a highly selective degrader of PARP1[1]. Target: Others. Smiles: OCCOCCOCCO CCOCCOCCOC...
| MW: | 581.61 D |
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Thalidomide-O-amido-C8-NH2 hydrochloride
Item number: TGM-T18817-100mg
Description: Thalidomide-O-amido-C8-NH2 hydrochloride is a synthetic conjugate of an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide and a linker. It can be utilized in the synthesis of PROTACs[1]. Target: Others. Smiles:...
| Keywords: | Thalidomide-O-amido-C8-NH2 hydrochloride (1950635-15-0 free base) |
| MW: | 494.97 D |
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Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
Item number: TGM-T18818-10mg
Description: Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs. Target: E3 Ligase Ligand-Linker Conjugate, Others. Smiles:...
| CAS | 2204226-02-6 |
| MW: | 454.862 D |
From 30.00€
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Meisoindigo
Item number: TGM-T1882-100mg
Description: Meisoindigo (Natura-alpha) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML). Target: Apoptosis. Smiles: CN1C(=O)\C(=C2\C(=O)Nc3ccccc23)c2ccccc12. References: Lee CC, et al. Leuk Lymphoma. 2010 May,51(5):897-905.
| Keywords: | Dian III, Methylisoindigotin, Natura-alpha, N-Methylisoindigotin |
| CAS | 97207-47-1 |
| MW: | 276.29 D |
From 60.00€
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Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
Item number: TGM-T18820-100mg
Description: Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein...
| CAS | 2245697-84-9 |
| MW: | 542.97 D |
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Thalidomide-O-amido-PEG4-azide
Item number: TGM-T18821-100mg
Description: Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) [1]. Target: Others. Smiles: [N-]=[N+]=NCCOCCOCCO CCOCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3. References: An S, et al. Small-molecule...
| CAS | 2411681-89-3 |
| MW: | 576.56 D |
From 56.00€
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Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
Item number: TGM-T18822-2mg
Description: Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating the Thalidomide-based cereblon ligand and a linker. Target: Ligand for E3 Ligase, Others. Smiles: Cl.O=C(NCCOCCOCCO CCOCCN)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3. References: James...
| CAS | 2245697-85-0 |
| MW: | 587.02 D |
47.00€
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Thalidomide-O-amido-PEG4-propargyl
Item number: TGM-T18823-100mg
Description: Thalidomide-O-amido-PEG4-propargyl is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1]. Target: Others. Smiles: O=C(NCCOCCOCCO CCOCC#C)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O. References: An S, et al. Small-molecule PROTACs: An emerging and...
| MW: | 545.54 D |
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Thalidomide-O-C6-NH2 TFA
Item number: TGM-T18824-100mg
Description: Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1]. Target: Others. Smiles: O=C(O)C(F)(F)F.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCCCCCN)C3C2=O)CC1. References: Erb MA, et al. Transcription control by the ENL YEATS domain...
| CAS | 1957235-99-2 |
| MW: | 487.43 D |
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Thalidomide-O-C6-NH2
Item number: TGM-T18825-100mg
Description: Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1]. Target: Others. Smiles: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCCCCCN)C3C2=O)CC1. References: Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia....
| CAS | 1957235-98-1 |
| MW: | 373.4 D |
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Thalidomide-O-PEG2-propargyl
Item number: TGM-T18826-2mg
Description: Thalidomide-O-PEG2-propargyl (E3 Ligase Ligand-Linker Conjugates 32) is a chemical compound that has been synthesized as a conjugate of an E3 ligase ligand and a linker. It incorporates the cereblon ligand based on Thalidomide, along with a 2-unit PEG linker. This compound is specifically designed for...
| Keywords: | E3 ligase Ligand-Linker Conjugates 32 |
| CAS | 2098487-52-4 |
| MW: | 400.38 D |
38.00€
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Thalidomide-O-PEG4-amine
Item number: TGM-T18827-100mg
Description: Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs [1]. Target: Others. Smiles: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCOCCOCCO CCOCCN)C3C2=O)CC1. References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy...
| CAS | 2401832-00-4 |
| MW: | 493.51 D |
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