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NEW
BRD4 ligand 6 TFA
Item number: TGM-T89433-10mg
Description: BRD4 Ligand 6TFA is the TFA salt form of BRD4 Ligand 6. It serves as a BRD4 ligand useful in the synthesis of BRD4 PROTACs, such as PROTAC BRD4 Degrader-26. Smiles: C(C(O)=O)(F)(F)F.CC=1C2=C(N3C([C@H](CC(NCCCN)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
| MW: | 571.02 D |
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PROTAC SMARCA2 degrader-4
Item number: TGM-T89436-10mg
Description: PROTACSMAR CA2 degrader-4 (Compound I-424) is a PROTAC degradative agent targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in MV411 and A549 cell lines with a DC50 of less than 100 nM and degrades SMARCA4 in MV411 with a DC50 exceeding 1 µM....
| MW: | 1009.27 D |
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UG-480
Item number: TGM-T89440-10mg
Description: UG-480 is a Gemini analog that effectively stabilizes the active VDR conformation. It exhibits antiproliferative effects in estrogen receptor-positive MCF-7 breast adenocarcinoma cells and is utilized in cancer research. Target: Vitamin
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CY5.5-PEG2000-Mal
Item number: TGM-T89447-10mg
Description: CY5.5-PEG2000-Mal is a compound designed for the preparation of fluorescently labeled molecules, consisting of a maleimide group (Mal), PEG2000, and the fluorescent dye CY5.5. Target: Others
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8K13-hz35-STING-D4-1203
Item number: TGM-T89448-10mg
Description: 8K13-hz35-STING-D4-1203 is an ADC (antibody-drug conjugate) linker compound. Target: Drug-Linker Conjugates for ADC. Smiles:...
| MW: | 1163 D |
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NEW
alphas1-CN f(143âEUR"149)
Item number: TGM-T89451-10mg
Description: alphas1-CN f(143â?"149) is an orally active peptide derived from casein. It exhibits angiotensin-converting enzyme (ACE) inhibitory activity (IC50=6.58 µM) alongside antihypertensive properties. Smiles:...
| MW: | 902 D |
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Lasioglossin-III
Item number: TGM-T89453-10mg
Description: Lasioglossin-III, an antimicrobial peptide, is derived from the venom of wild bees. It exhibits significant antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as antifungal and antitumor properties. Lasioglossin-III demonstrates cytotoxic effects on three cancer cell...
| MW: | 1765.28 D |
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Rp-8-pCPT-cGMPS
Item number: TGM-T89454-10mg
Description: Rp-8-pCPT-cGMPS is a competitive inhibitor of cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) with a Ki of 0.5 µM. This compound exhibits increased lipophilicity, allowing it to penetrate cell membranes more readily and achieve sufficient intracellular concentrations to inhibit PKG....
| MW: | 503.88 D |
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LSD1-IN-31
Item number: TGM-T89469-10mg
Description: LSD1-IN-31 (compound 11e) interacts directly with the LSD1/CoREST complex, inhibiting the demethylase activity of LSD1. This inhibition of LSD1 demethylase activity impacts the downstream IkappaB/NF-kappaB signaling pathway. Furthermore, LSD1-IN-31 can inhibit osteoclast-mediated bone loss both in vitro...
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CK1-IN-2 hydrochloride
Item number: TGM-T89470-10mg
Description: CK1-IN-2 (compound Nr.4) hydrochloride is an effective inhibitor of CK1, exhibiting inhibitory IC50 values of 123 nM, 19.8 nM, 26.8 nM, and 74.3 nM against CK1a, CK1d, CK1e, and p38a respectively. Smiles: Cl.O=C1OCC2=NC=CC(C3=CN(N=C3C=4C=CC(F)=CC4)C)=C12
| MW: | 345.76 D |
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EGFR/HER2-IN-16
Item number: TGM-T89472-10mg
Description: EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC50=6.15 nM) and HER-2 (IC50=9.78 nM), exhibiting antitumor activity. This compound inhibits migration of SK-BR-3 cells, arrests the cell cycle in the G0/G1 phase, and induces cell apoptosis (apoptosis). Demonstrating strong...
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HDAC8-IN-10
Item number: TGM-T89475-10mg
Description: HDAC8-IN-10 (compound 15) serves as a potent inhibitor of HDAC8, exhibiting an IC50 value of 7.6 nM. It also acts as a ligand for the HDAC8 target protein, utilized in the synthesis of PROTAC YX862. Target: HDAC
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