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eIF4A i28
Item number: Cay45394-1
eIF4A i28 is an inhibitor of eukaryotic translation initiation factor 4A (eIF4A). It inhibits the ATPase and helicase activities of eIF4A with IC50 values of 8.6 and 6.6 µM, respectively, in cell-free assays. eIF4A i28 reduces the viability of BJAB Burkitt lymphoma cells (EC50 = 0.46 µM).. SMILES:...
| Keywords: | Eukaryotic Translation Initiation Factor 4A i28, 2-[5-(4-butylphenyl)-2-furanyl]-6-nitro-4-quinolinecarboxylic acid |
| Application: | EIF4A inhibitor |
| CAS | 2861994-92-3 |
| MW: | 416.43 D |
From 49.00€
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TSPO Ligand-1
Item number: Cay45402-10
TSPO ligand-1 is an intermediate in the synthesis of 2-phenylindolglyoxylamide derivatives that bind translocator protein, formerly known as translocator protein (18 kDa) (TSPO). It has been used in the synthesis of fluorescent probes that are selective for translocator protein. TSPO ligand-1 has also been used in...
| Keywords: | Translocator Protein Ligand-1, alpha-oxo-2-phenyl-1H-indole-3-acetyl chloride |
| Application: | 2-phenylindolglyoxylamide derivative intermediate, TSPO binding |
| CAS | 4560-08-1 |
| MW: | 283.71 D |
From 64.00€
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Iproniazid
Item number: Cay45450-100
Iproniazid is an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 6.56 and 7.54 µM, respectively). It reduces immobility in an open swimming test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg. Iproniazid (300 and 400 mg/kg) induces acute hepatic necrosis in...
| Keywords: | 2-(1-methylethyl)hydrazide, 4-pyridinecarboxylic acid |
| Application: | MAO-A / MAO-B inhibitor |
| CAS | 54-92-2 |
| MW: | 179.22 D |
From 35.00€
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Tracazolate
Item number: Cay45457-1
Tracazolate is a positive allosteric modulator of the GABAA receptor (GABAAR). It potentiates GABA-stimulated currents in X. laevis oocytes expressing alpha1beta3gamma2s and alpha1beta1delta subunit-containing GABAARs (EC50s = 1.5 and 16.7 µM, respectively) and increases the maximal response to GABA in X. laevis...
| Keywords: | ICI 136753, 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester |
| Application: | GABAA receptor positive allosteric modulator |
| CAS | 41094-88-6 |
| MW: | 304.39 D |
From 139.00€
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Velusetrag
Item number: Cay45464-10
Velusetrag is an agonist of the serotonin (5-HT) receptor subtype 5-HT4. It increases cAMP accumulation in HEK293 cells expressing human 5-HT4(c), 5-HT4(d), and 5-HT4(g) receptors (EC50s = 5.01, 2.51, and 6.31 nM, respectively). Velusetrag is greater than 500-fold selective for the 5-HT4 receptor over ten other 5-HT...
| Keywords: | TD-5108,... |
| Application: | 5-HT4 receptor agonist |
| CAS | 866933-46-2 |
| MW: | 504.65 D |
From 410.00€
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Eclitasertib
Item number: Cay45472-1
Eclitasertib is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 0.0375 µM). It inhibits necroptosis induced by TNF-alpha, a Smac mimetic, and Z-VAD-FMK in HT-29 cells (EC50 = 0.0154 µM, respectively). Eclitasertib (4 nM) inhibits necroptosis induced by IFN-gamma, TNF-alpha, Z-VAD, and...
| Keywords: | DNL758, SAR443122,... |
| Application: | RIPK1 inhibitor |
| CAS | 2125450-76-0 |
| MW: | 378.39 D |
From 42.00€
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VEGFR2 Kinase Inhibitor IV
Item number: Cay45474-1
VEGFR2 kinase inhibitor IV is an inhibitor of VEGFR2 (IC50 = 19 nM). It is greater than 100-fold selective for VEGFR2 over FGFR1 and Src but only 1.8-, 10-, and 10-fold selective over PDGFRbeta, FLT1, and FLT2, respectively. VEGFR2 kinase inhibitor IV inhibits mitogenesis in human umbilical vein endothelial cells...
| Keywords: | Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor IV,... |
| Application: | VEGFR2 inhibitor |
| CAS | 216661-57-3 |
| MW: | 307.37 D |
From 278.00€
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RWJ 60475
Item number: Cay45483-1
RWJ 60475 is an inhibitor of CD45 (IC50 = 2 µM).. SMILES: BrC(C=C1)=CC=C1OC(C(C(P(O)(O)=O)O)=C2)=CC=C2[N+]([O-])=O. InChi Code: InChI=1S/C13H11BrNO7P/c14-8-1-4-10(5-2-8)22-12-6-3-9(15(17)18)7-11(12)13(16)23(19,20)21/h1-7,13,16H,(H2,19,20,21). InChi Key: JJKCSZKQYMYARX-UHFFFAOYSA-N
| Keywords: | P-[[2-(4-bromophenoxy)-5-nitrophenyl]hydroxymethyl]-phosphonic acid |
| Application: | CD45 inhibitor |
| CAS | 204130-08-5 |
| MW: | 404.11 D |
From 83.00€
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MNI137
Item number: Cay45486-10
MNI137 is a negative allosteric modulator of metabotropic glutamate receptor 2 (mGluR2). It selectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing human mGluR2 (IC50 = 11.4 nM) over HEK293 cells expressing rat mGluR1, -5, -7, or -8 and those expressing human mGluR4 at 10 µM.. SMILES:...
| Keywords: | 4-(8-bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile |
| Application: | MGluR2 negative allosteric modulator |
| CAS | 946619-21-2 |
| MW: | 341.17 D |
From 124.00€
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YIC-C8-434
Item number: Cay45487-1
YIC-C8-434 is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT, IC50 = 11 nM in isolated rat hepatic microsomes). It reduces plasma cholesterol levels by 79% in rats when administered at a dose of 0.005% in a high-cholesterol diet. Oral administration of YIC-C8-434 (8.3 mg/kg per day) reduces cholesterol...
| Keywords: | (2E)-3-[3,5-dimethoxy-4-(octyloxy)phenyl]-1-[4-(3,4-dimethylphenyl)-1-piperazinyl]-2-propen-1-one |
| Application: | ACAT inhibitor |
| CAS | 214265-97-1 |
| MW: | 508.7 D |
From 91.00€
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LCK Inhibitor II
Item number: Cay45496-1
LCK inhibitor II is an inhibitor of LCK (IC50 = 3 nM in a cell-free assay). It reduces IL-2 levels in Jurkat cells (IC50 = 54 nM). SMILES: OC1=CC=C(C)C(NC2=NC(N3C4=C(N=C3)C=CC=C4)=NC(OCCN5CCOCC5)=C2)=C1. InChi Code:...
| Keywords: | Lymphocyte-specific Protein Tyrosine Kinase II,... |
| Application: | LCK (Lymphocyte cell-specific protein-tyrosine kinase) inhibitor |
| CAS | 918870-43-6 |
| MW: | 446.51 D |
From 139.00€
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Mz325
Item number: Cay45518-1
Mz325 is a dual inhibitor of histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2, IC50s = 0.043 and 0.32 µM, respectively, in a cell-free assay). Mz325 is a heterobifunctional molecule that contains an HDAC6 inhibitor conjugated to a SIRT2 inhibitor via a triazole linker. It is selective for HDAC6 and SIRT2 over...
| Keywords: | N-butyl-4-[[3-[[2-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]-5-thiazolyl]methyl]phenoxy]methyl]-N-[[4-[(hydroxyam... |
| Application: | HDAC6 / SIRT2 dual inhibitor |
| CAS | 3032670-12-2 |
| MW: | 771.96 D |
From 55.00€
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