No results were found for the filter!
5'-Iodo-2',5'-dideoxy-thymidine 3'-CE Phosphoramidite
Item number: Cay44585-10
5'-Iodo-2',5'-dideoxy-thymidine 3'-CE phosphoramidite is a nucleoside building block that has been used in the synthesis of ssDNA and cyclized ssDNA.. SMILES: O=C1N(C=C(C(N1)=O)C)[C@H]2C[C@@H]([C@H](O2)CI)OP(OCCC#N)N(C(C)C)C(C)C. InChi Code:...
| Keywords: | 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]5'-deoxy-5'-iodo-thymidine |
| Application: | Nucleoside building block |
| CAS | 195207-78-4 |
| MW: | 552.3 D |
From 49.00€
*
ABEI
Item number: Cay45127-100
ABEI is a chemiluminescent probe and a derivative of isoluminol (Cay45126). It has been used for the detection of reactive oxygen species (ROS). ABEI reacts with amine-, thiol-, and carboxylic acid-moieties to form conjugates with small molecules for their detection in HPLC applications. It also has been conjugated...
| Keywords: | 7-[(4-aminobutyl)ethylamino]-4-hydroxy-1(2H)-phthalazinone |
| Application: | Chemiluminescent probe, ROS detection |
| CAS | 66612-29-1 |
| MW: | 276.34 D |
From 189.00€
*
FK-453
Item number: Cay45327-1
FK-453 is an adenosine A1 receptor antagonist (Ki = 18 nM). It is selective for the adenosine A1 receptor over the adenosine A2A and A3 receptors (Kis = 1,300 and 2,800 nM, respectively). FK-453 reduces adenosine-induced negative inotropic activity in isolated guinea pig atrial strips (IC50 = 560 pM).2 It has...
| Keywords: | (2E)-1-[(2R)-2-(2-hydroxyethyl)-1-piperidinyl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2-propen-1-one |
| Application: | Adenosine A1 receptor antagonist |
| CAS | 121524-18-3 |
| MW: | 375.47 D |
From 174.00€
*
Rezvilutamide
Item number: Cay45332-10
Rezvilutamide is a non-steroidal androgen receptor antagonist. It reduces secretion of prostate-specific androgen (PSA) from LNCaP prostate cancer cells (IC50 = 22 nM) and reduces proliferation of the same cells (IC50 = 33 nM). Formulations containing rezvilutamide have been used in the treatment of prostate...
| Keywords: | SHR-3680,... |
| Application: | Non-steroidal androgen receptor antagonist |
| CAS | 1572045-62-5 |
| MW: | 479.47 D |
From 271.00€
*
Pincainide
Item number: Cay45339-1
Pincainide is a calcium channel inhibitor. It reduces norepinephrine-induced calcium influx and increases calcium efflux in isolated rat aortic strips. Pincainide reduces phasic and tonic contractions induced by norepinephrine (IC50s = 880 and 780 µM, respectively) and high potassium (IC50s = 620 and 670 µM,...
| Keywords: | IQB-M-81, N-(2,6-dimethylphenyl)hexahydro-1H-azepine-1-acetamide |
| Application: | Calcium channel inhibitor |
| CAS | 83471-41-4 |
| MW: | 260.38 D |
From 139.00€
*
UC-112
Item number: Cay45378-10
UC-112 is a Smac mimetic. It reduces the level of survivin and induces apoptosis in A375 melanoma and PC3 prostate cancer cells and inhibits the growth of A375, M14 human melanoma, PC3 and DU145 prostate cancer cells (IC50s = 1.6, 2.5, 0.7, and 3.4 µM, respectively). In vivo, UC-112 (20 and 40 mg/kg) reduces tumor...
| Keywords: | 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol |
| Application: | Smac mimetic |
| CAS | 383392-66-3 |
| MW: | 348.45 D |
From 189.00€
*
hGPR91 Antagonist 3
Item number: Cay45388-1
hGPR91 antagonist 3 is an antagonist of succinate receptor 1, also known as G protein-coupled receptor 91 (GPR91, IC50 = 35 nM).. SMILES: FC(F)(C(C=C(C1=NOC(CNC(CCCC2=CC=C(C=CC=N3)C3=N2)=O)=C1)C=C4)=C4F)F. InChi Code:...
| Keywords: | Human G Protein-coupled Receptor 91 Antagonist 3, Human GPR91 Antagonist 3, Succinate Receptor 1 Antagonist 3, SUCNR1... |
| Application: | Succinate receptor 1 (GPR91) antagonist |
| CAS | 1314796-31-0 |
| MW: | 458.42 D |
From 110.00€
*
M435-1279
Item number: Cay45401-1
M435-1279 is an inhibitor of ubiquitin-conjugating enzyme E2T (UBE2T). It binds to UBE2T (Kd = 50.5 µM), inhibits UBE2T-mediated degradation of receptor for activated C kinase 1 (RACK1), and reduces hyperactive Wnt/beta-catenin signaling. M435-1279 reduces the viability of MKN45 and AGS gastric cancer cells when...
| Keywords: | N-[4-(aminosulfonyl)phenyl]-1,2,5,6,7,8-hexahydro-4-hydroxy-2-oxo-[1]benzothieno[2,3-b]pyridine-3-carboxamide |
| Application: | UBE2T inhibitor |
| CAS | 1359431-16-5 |
| MW: | 419.47 D |
From 69.00€
*
NO-Pravastatin
Item number: Cay10006044-1
NO-pravastatin is a derivative of pravastatin (Cay10010343) that contains a nitric oxide-releasing moiety. It induces cGMP formation in PC12 cells (EC50 = 2.3 µM) and inhibits the proliferation of isolated rat aortic smooth muscle cells (IC50 = 2.2 µM). NO-pravastatin reduces inducible nitric oxide synthase (iNOS)...
| Keywords: | NCX 6550,... |
| Application: | Nitric oxide-releasing moiety containing pravastatin derivative, HMG-CoA reductase inhibitor |
| CAS | 733034-46-3 |
| MW: | 541.64 D |
From 35.00€
*
RA839
Item number: Cay42640-1
RA839 is an inhibitor of the protein-protein interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2). It binds non-covalently to the Keap1 Kelch domain (Kd = ~6 µM). RA839 increases Nrf2-dependent transcription driven by antioxidant response element...
| Keywords: | 1-[4-[[(2,3,5,6-tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid |
| Application: | Keap1-Nrf2 protein-protein interaction inhibitor |
| CAS | 1832713-02-6 |
| MW: | 452.57 D |
From 35.00€
*
5'-DMTr-dA(Bz)-Methyl Phosphonamidite
Item number: Cay43321-100
5'-DMTr-dA(Bz)-methyl phosphonamidite is a nuceloside building block. SMILES: CC(N(P(O[C@@H](C1)[C@H](O[C@H]1N2C=NC3=C(NC(C4=CC=CC=C4)=O)N=CN=C23)COC(C(C=C5)=CC=C5OC)(C6=CC=CC=C6)C(C=C7)=CC=C7OC)C)C(C)C)C. InChi Code:...
| Keywords: | 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite] N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'deoxy-adenosine |
| Application: | Nucleoside building block |
| CAS | 114079-05-9 |
| MW: | 802.91 D |
From 165.00€
*
GEM144
Item number: Cay44647-1
GEM144 is a dual inhibitor of DNA polymerase alpha (POLA1) and histone deacetylase 11 (HDAC11). It inhibits the primer extension activity of POLA1 in a cell-free assay when used at concentrations ranging from 10 to 50 µM and increases acetylation of alpha-tubulin at lysine 40 in H460 lung cancer cells at 0.4 µM. It...
| Keywords: | (2E)-3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-2-propenoic acid |
| Application: | POLA1 / HDAC11 dual inhibitor |
| CAS | 2487526-28-1 |
| MW: | 461.56 D |
From 69.00€
*