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Cy5 NHS ester
Item number: Cay45624-1
Cy5 NHS ester is an amine-reactive fluorochrome. It displays excitation/emission maxima of 646/662 nm, respectively. Cy5 NHS ester has been conjugated to a peptide motif based on a Factor VII-activating protease (FSAP) substrate for use as an activity-based probe for the FSAP serine protease domain (SPD).. SMILES:...
| Keywords: | Cy5 N-hydroxysuccinimide ester, Cyanine 5 NHS ester,... |
| Application: | Amine-reactive fluorochrome |
| CAS | 1263093-76-0 |
| MW: | 667.55 D |
From 40.00€
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4,4'-Bipyridyl
Item number: Cay45661-10
4,4'-Bipyridyl is a building block that has been used as a ligand in coordination polymer chemistry and the synthesis of metal-organic frameworks (MOFs). It is also a synthetic intermediate that has been used in the synthesis of the herbicide paraquat (Cay38521).. SMILES: C1(C2=CC=NC=C2)=CC=NC=C1. InChi Code:...
| Keywords: | 4,4'B, 4,4'-Dipyridyl, BPY, NSC 404423 |
| Application: | Building block, synthetic intermediate |
| CAS | 553-26-4 |
| MW: | 156.19 D |
From 35.00€
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HA-1004
Item number: Cay45680-1
HA-1004 is an inhibitor of PKG, PKA, myosin light-chain kinase (MLCK), and PKC (Kis = 1.3, 2.3, 70 and 18 µM, respectively, in cell-free assays). It induces relaxation of isolated rabbit aortic strips precontracted with histamine (Cay33828), serotonin (Cay14332), A23187 (Cay11016), angiotensin II (Cay17150), or...
| Keywords: | N-[2-[(aminoiminomethyl)amino]ethyl]-5-isoquinolinesulfonamide |
| Application: | PKG inhibitor |
| CAS | 91742-10-8 |
| MW: | 293.35 D |
From 291.00€
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L-Dihydroorotic Acid
Item number: Cay45688-1
L-Dihydroorotic acid is an intermediate in the de novo pyrimidine biosynthesis pathway. It is formed from carbamoyl phosphate by dihydroorotase and converted into orotic acid by dihydroorotate dehydrogenase (DHODH).. SMILES: OC([C@@H]1CC(NC(N1)=O)=O)=O. InChi Code:...
| Keywords: | L-Dihydroorotate, hexahydro-2,6-dioxo-4S-pyrimidinecarboxylic acid |
| Application: | Pyrimidine biosynthesis intermediate |
| CAS | 5988-19-2 |
| MW: | 158.11 D |
From 244.00€
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HyNic NHS ester
Item number: Cay45697-10
HyNic NHS ester is a heterobifunctional linker molecule. It contains an amine-reactive N-hydroxysuccinimide (NHS) moiety and a hydrazine moiety that reacts with the aldehyde functional group in SFB (succinimidyl 4-formylbenzoate, Item No. 30477) to form a bis-aryl hydrazone linker that is quantifiable...
| Keywords: | HyNic N-hydroxysuccinimide ester, SANH, S-HyNic, 6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinecarboxylic acid,... |
| Application: | Heterobifunctional linker molecule |
| CAS | 362522-50-7 |
| MW: | 290.28 D |
From 91.00€
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2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)
Item number: Cay45704-10
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a derivative of DOTA (Cay43655) containing three carboxylate moieties protected by tert-butyloxycarbonyl (Boc). It chelates metals upon deprotection with trifluoroacetic acid. It has been used in the synthesis of radiolabeled probes for radioimmunoimaging.. SMILES:...
| Keywords: | 10-[2-[(2-aminoethyl)amino]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, 1,4,7-tris(1,1-dimethylethyl)... |
| Application: | Boc-protected DOTA derivative, radiolabeled probe synthesis |
| CAS | 173308-19-5 |
| MW: | 614.83 D |
From 35.00€
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ZT-1a
Item number: Cay45727-1
ZT-1a is an inhibitor of STE20/SPS1-related proline-alanine-rich protein kinase (SPAK, IC50 = 46.7 µM in a cell-free assay). It reduces phosphorylation of Na-K-Cl cotransporter 1 (NKCC1), Na-K cotransporter 2 (KCC2), and KCC3 in HEK293 cells. ZT-1a reduces cerebrospinal fluid (CSF) hypersecretion in a rat model of...
| Keywords: | 5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-benzamide |
| Application: | SPAK inhibitor |
| CAS | 212135-62-1 |
| MW: | 445.72 D |
From 69.00€
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SKLB197
Item number: Cay45728-10
SKLB197 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR) (IC50 = 0.013 µM). It is selective for ATR over a panel of 402 other kinases (IC50s = >1 µM). SKLB197 reduces growth in cancer cell lines deficient in ataxia-telangiectasia mutated kinase (ATM, IC50s = 0.13-0.66 µM) to a greater...
| Keywords: | 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1methyl-1H-pyrazol-5-yl)-quinazoline |
| Application: | ATR inhibitor |
| CAS | 2713577-16-1 |
| MW: | 424.51 D |
From 249.00€
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ARN3261
Item number: Cay45729-10
ARN3261 is an inhibitor of salt-inducible kinase 2 (SIK2). It induces apoptosis in OVCAR-8, SKOV3, and OC 316 ovarian cancer cells and inhibits growth in ten ovarian cancer cell lines (IC50s = 0.8-2.6 µM). ARN3261 enhances sensitivity to carboplatin (Cay13112) in both carboplatin-sensitive and -resistant ovarian...
| Keywords: | GRN-300, 3-(3,5-difluoro-2-methoxyphenyl)-5-[1[1-(methylsulfonyl)-4-piperidinyl]-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine |
| Application: | SIK2 inhibitor |
| CAS | 1613711-28-6 |
| MW: | 487.53 D |
From 78.00€
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dTRIM24
Item number: Cay45749-1
dTRIM24 is a proteolysis-targeting chimera (PROTAC) containing the ubiquitin ligase TRIM24 ligand IACS-7e conjugated to the von Hippel-Lindau (VHL) ligand VL-269 via a PEG linker. It induces degradation of TRIM24 in HEK293-FT cells at 0.25-5 µM with maximum degradation at 5 µM. dTRIM24 (5 µM) reduces growth and...
| Keywords: | (2S,4R)-1-((S)-15-(tert-butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfa... |
| Application: | TRIM24 degradation driving PROTAC |
| CAS | 2170695-14-2 |
| MW: | 1113.31 D |
From 116.00€
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25-hydroxy Vitamin D3 3-LC-LC-Biotin
Item number: Cay45788-100
25-hydroxy Vitamin D3 3-LC-LC-biotin is a biotinylated form of 25-hydroxy vitamin D3 (Cay9000683).. SMILES: [H][C@]([C@]1(C)CCC/2)(CC[C@]1([H])[C@H](C)CCCC(C)(O)C)C2=C\C=C3C[C@@H](OCCCNC(CCCCCNC(CCCCCNC(CCCC[C@@H]4SC[C@@]5(NC(N[C@]45[H])=O)[H])=O)=O)=O)CCC\3=C. InChi Code:...
| Keywords: | N-(3-(((S,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-... |
| Application: | 25-hydroxy vitamin D3, biotinylated form |
| MW: | 910.36 D |
315.00€
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BMS-1001
Item number: Cay45922-1
BMS-1001 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1, IC50 = 2.25 nM in a cell-free assay). It has been used in the synthesis of a proteolysis-targeting chimera (PROTAC) that drives PD-L1 degradation in MC-38 colon cancer cells. Conjugates...
| Keywords: | N-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methyl]-D-s... |
| Application: | PD-1/PD-L1 protein-protein interaction inhibitor |
| CAS | 2113650-03-4 |
| MW: | 594.66 D |
From 124.00€
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