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Bafilomycin A1 (solution)
Item number: Cay46024-1
Bafilomycin A1 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases, Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases....
| Keywords: | NSC 381866,... |
| Application: | Bioactive bacterial metabolite |
| CAS | 88899-55-2 |
| MW: | 622.84 D |
From 248.00€
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Hericenone D
Item number: Cay39785-1
Hericenone D is a monoterpenoid originally isolated from H. erinaceum.. SMILES: C/C(C)=C\C(C/C(C)=C/CC1=C(C(C=O)=C(C=C1OC)COC(CCCCCCCCCCCCCCCCC)=O)O)=O. InChi Code:...
| Keywords: | octadecanoic acid, [4-[(2E)-3,7-dimethyl-5-oxo-2,6-octadien-1-yl]-2-formyl-3-hydroxy-5-methoxyphenyl]methyl ester |
| Application: | Monoterpenoid |
| CAS | 137592-04-2 |
| MW: | 598.85 D |
From 118.00€
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Shearinine B
Item number: Cay45476-1
Shearinine B is an indole diterpene originally isolated from E. shearii that has antiinsectan activity. Shearinine B (100 ppm in the diet) reduces the growth rate of H. zea larvae and the feeding rate of C. hemipterus larvae by 94 and 50%, respectively. It also induces 84% mortality in S. frugiperda larvae in a leaf...
| Keywords: | (2R,4bS,6aS,9aS,15bS,15cR,17aS)-5,6,6a,7,9,9a,10,12,15,15b,15c,16,17,17a-tetradecahydro-4b-hydroxy-2-(1-hydroxy-1-methylet... |
| Application: | Indole diterpene, antiinsectan agent |
| CAS | 163136-25-2 |
| MW: | 585.78 D |
From 235.00€
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Dabuzalgron (hydrochloride)
Item number: Cay45580-10
Dabuzalgron is a partial agonist of the alpha1A-adrenergic receptor (alpha1A-AR). It selectively binds to alpha1A-ARs over alpha1B- and alpha1D-ARs in CHO-K1 cells expressing the recombinant human receptors (Kis = 0.041, 1.6, and 6.5 µM, respectively) and selectively induces inositol phosphate accumulation in...
| Keywords: | Ro 115-1240, N-[6-chloro-3-[(4,5-dihydro-1H-imidazol-2-yl)methoxy]-2-methylphenyl]-methanesulfonamide, monohydrochloride |
| Application: | Alpha1A-AR partial agonist |
| CAS | 219311-43-0 |
| MW: | 354.25 D |
From 208.00€
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HC-5404
Item number: Cay45588-1
HC-5404 is an inhibitor of protein kinase R-like ER kinase (PERK, IC50 = 4 nM in a cell-free assay). It is selective for PERK over a panel of 25 kinases at 1 mM. HC-5404 reduces the levels of phosphorylated eukaryotic translation initiation factor 2alpha subunit (eIF2alpha) in HEK293 cells (IC50 = 33 nM). It reduces...
| Keywords: | LY-4,... |
| Application: | PERK (EIF2AK3) inhibitor |
| CAS | 2247396-91-2 |
| MW: | 454.48 D |
From 69.00€
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E3 Ligase Ligand 18
Item number: Cay45600-10
E3 ligase ligand 18 is a substituted purine derivative.. SMILES: NC(NC1=C2N=C(N1CC3=CC=C(Cl)C=C3)SC[C@H](NC(C)=O)C(O)=O)=NC2=O. InChi Code: InChI=1S/C17H17ClN6O4S/c1-8(25)20-11(15(27)28)7-29-17-21-12-13(22-16(19)23-14(12)26)24(17)6-9-2-4-10(18)5-3-9/h2-5,11H,6-7H2,1H3,(H,20,25)(H,27,28)(H3,19,22,23,26)/t11-/m0/s1....
| Keywords: | N-acetyl-S-[2-amino-9-[(4-chlorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]-L-cysteine |
| Application: | Substituted purine derivative |
| CAS | 2241669-88-3 |
| MW: | 436.87 D |
From 139.00€
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SKLB03220
Item number: Cay45614-1
SKLB03220 is a covalent inhibitor of the histone-lysine methyltransferase enhancer of zeste homolog 2 (EZH2, IC50 = 1.72 nM). It also inhibits EZH2A677G, EZH2Y641N, and EZH2Y641F, mutations found in various cancers, when used at a concentration of 10 nM. SKLB03220 is selective for EZH2 over a variety of other...
| Keywords: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2',4-dimethyl-5'-[(1-oxo-2... |
| Application: | Covalent EZH2 inhibitor |
| CAS | 2852050-29-2 |
| MW: | 556.71 D |
From 35.00€
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Spiraeoside
Item number: Cay45667-1
Spiraeoside is a flavonoid glycoside that has been found in F. ulmaria and has diverse biological activities. It scavenges DPPH (Cay14805) and hydroxyl radicals (IC50s = 19.54 and 5.1 µg/ml, respectively) and inhibits beta-glucuronidase and lipoxygenase (LO) in cell-free assays. Spiraeoside (15 µg/ml) induces cell...
| Keywords: | Quercetin 4'-O-glucoside, Quercetin-4-O-beta-D-glycoside,... |
| Application: | Bioactive flavonoid glycoside |
| CAS | 20229-56-5 |
| MW: | 464.38 D |
From 91.00€
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2-(1-(3-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)-5-fluoro-...
Item number: Cay45721-10
2-(1-(3-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)-5-fluoro-1-methyl-1H-indazol-6-yl)-4-hydroxypiperidin-4-yl)acetic acid is a proteolysis-targeting chimera (PROTAC) building block. It has been used in the synthesis of a PROTAC that drives mutant B-RAF degradation.. SMILES:...
| Keywords: | 1-[5-fluoro-1-methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-1H-indazol-6-yl]-4-hydroxy-4-piperidineacetic acid |
| Application: | PROTAC building block |
| CAS | 2654826-81-8 |
| MW: | 419.41 D |
From 83.00€
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Brefeldin A
Item number: Cay11861-5
Brefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. BFA directly and...
| Keywords: | Ascotoxin, BFA, Cyanein, Decumbin, Nectrolide, NSC 107456, NSC 244390, NSC 56310, NSC 89671, Synergisidin,... |
| Application: | Endosomal trafficking studies |
| CAS | 20350-15-6 |
| MW: | 280.4 D |
From 70.00€
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A23187
Item number: Cay11016-10
A23187 is a calcium ionophore and a microbial metabolite that has been found in S. chartreusensis. It induces calcium overload and mitochondrial apoptosis in HEK293 cells when used at a concentration of 5 µM. A23187 (5 µM) induces the production of reactive oxygen species (ROS) and neutrophil extracellular trap...
| Keywords: | Calcimycin,... |
| Application: | Cation ionophore |
| CAS | 52665-69-7 |
| MW: | 523.6 D |
From 60.00€
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Acetoacetyl-Coenzyme A (sodium salt hydrate)
Item number: Cay21219-10
Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway. It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis. Acetoacetyl-CoA...
| Keywords: | Acetoacetyl-CoA, S-(3-oxobutanoate) coenzyme A, trisodium salt, tetrahydrate |
| Application: | HMG-CoA precursor |
| MW: | 989.6 D |
From 116.00€
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