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(R)-STU104
Item number: Cay45375-1
(R)-STU104 is an inhibitor of the protein-protein interaction between TGF-beta-activated kinase 1 (TAK1) and MAP kinase kinase 3 (MKK3). It binds MKK3 (KD = 71 nM), inhibits the phosphorylation of MKK3 in RAW 264.7 macrophages (IC50 = 4 µM), and disrupts the interaction between MKK3 and TAK1 in the same cells....
| Keywords: | (3R)-2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-1H-inden-1-one |
| Application: | TAK1-MKK3 protein-protein interaction inhibitor |
| CAS | 2767124-77-4 |
| MW: | 298.34 D |
From 69.00€
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UC-112
Item number: Cay45378-10
UC-112 is a Smac mimetic. It reduces the level of survivin and induces apoptosis in A375 melanoma and PC3 prostate cancer cells and inhibits the growth of A375, M14 human melanoma, PC3 and DU145 prostate cancer cells (IC50s = 1.6, 2.5, 0.7, and 3.4 µM, respectively). In vivo, UC-112 (20 and 40 mg/kg) reduces tumor...
| Keywords: | 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol |
| Application: | Smac mimetic |
| CAS | 383392-66-3 |
| MW: | 348.45 D |
From 189.00€
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Plk1-IN-4
Item number: Cay45382-1
Plk1-IN-4 is an inhibitor of polo-like kinase 1 (Plk1, IC50 = 0.508 nM in a cell-free assay). It inhibits the growth of HepG2 and SMMC-7721 hepatocellular carcinoma cells (IC50s = 11.1 and 70.9 nM, respectively) and induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells. Plk1-IN-4 (30 mg/kg)...
| Keywords: | Polo-like Kinase 1 Inhibitor 4, Polo-like Kinase 1-IN-4,... |
| Application: | Plk1 inhibitor |
| CAS | 2622273-55-4 |
| MW: | 550.56 D |
From 76.00€
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PROTAC Bcl-2 Degrader-1
Item number: Cay45385-1
PROTAC Bcl-2 degrader-1 is a proteolysis-targeting chimera (PROTAC) composed of a Bcl-2 inhibitor conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay19877) via a PEG linker. It induces the degradation of Bcl-2 in HeLa cells with a half-maximal degradation concentration (DC50) value of 3 µM. PROTAC Bcl-2...
| Keywords: | PROTAC BCL2 Degrader-1, Proteolysis-targeting Chimera Bcl-2 Degrader-1, Proteolysis-targeting Chimera BCL2 Degrader-1,... |
| Application: | Bcl-2 degradation driving PROTAC |
| CAS | 2378801-85-3 |
| MW: | 941.85 D |
From 485.00€
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hGPR91 Antagonist 3
Item number: Cay45388-1
hGPR91 antagonist 3 is an antagonist of succinate receptor 1, also known as G protein-coupled receptor 91 (GPR91, IC50 = 35 nM).. SMILES: FC(F)(C(C=C(C1=NOC(CNC(CCCC2=CC=C(C=CC=N3)C3=N2)=O)=C1)C=C4)=C4F)F. InChi Code:...
| Keywords: | Human G Protein-coupled Receptor 91 Antagonist 3, Human GPR91 Antagonist 3, Succinate Receptor 1 Antagonist 3, SUCNR1... |
| Application: | Succinate receptor 1 (GPR91) antagonist |
| CAS | 1314796-31-0 |
| MW: | 458.42 D |
From 110.00€
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TNF-alpha-IN-1
Item number: Cay45390-1
TNF-alpha-IN-1 is a glutarimide-substituted phthalimide.. SMILES: ClCC(NCC(C=CC=C1C2=O)=C1C(N2C(C(N3)=O)CCC3=O)=O)=O. InChi Code: InChI=1S/C16H14ClN3O5/c17-6-12(22)18-7-8-2-1-3-9-13(8)16(25)20(15(9)24)10-4-5-11(21)19-14(10)23/h1-3,10H,4-7H2,(H,18,22)(H,19,21,23). InChi Key: XRAYWKDMFVKUTJ-UHFFFAOYSA-N
| Keywords: | Tumor Necrosis Factor-alpha Inhibitor 1, Tumor Necrosis Factor-alpha-IN-1,... |
| Application: | Phthalimide |
| CAS | 444287-49-4 |
| MW: | 363.75 D |
From 37.00€
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eIF4A i28
Item number: Cay45394-1
eIF4A i28 is an inhibitor of eukaryotic translation initiation factor 4A (eIF4A). It inhibits the ATPase and helicase activities of eIF4A with IC50 values of 8.6 and 6.6 µM, respectively, in cell-free assays. eIF4A i28 reduces the viability of BJAB Burkitt lymphoma cells (EC50 = 0.46 µM).. SMILES:...
| Keywords: | Eukaryotic Translation Initiation Factor 4A i28, 2-[5-(4-butylphenyl)-2-furanyl]-6-nitro-4-quinolinecarboxylic acid |
| Application: | EIF4A inhibitor |
| CAS | 2861994-92-3 |
| MW: | 416.43 D |
From 49.00€
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M435-1279
Item number: Cay45401-1
M435-1279 is an inhibitor of ubiquitin-conjugating enzyme E2T (UBE2T). It binds to UBE2T (Kd = 50.5 µM), inhibits UBE2T-mediated degradation of receptor for activated C kinase 1 (RACK1), and reduces hyperactive Wnt/beta-catenin signaling. M435-1279 reduces the viability of MKN45 and AGS gastric cancer cells when...
| Keywords: | N-[4-(aminosulfonyl)phenyl]-1,2,5,6,7,8-hexahydro-4-hydroxy-2-oxo-[1]benzothieno[2,3-b]pyridine-3-carboxamide |
| Application: | UBE2T inhibitor |
| CAS | 1359431-16-5 |
| MW: | 419.47 D |
From 69.00€
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TSPO Ligand-1
Item number: Cay45402-10
TSPO ligand-1 is an intermediate in the synthesis of 2-phenylindolglyoxylamide derivatives that bind translocator protein, formerly known as translocator protein (18 kDa) (TSPO). It has been used in the synthesis of fluorescent probes that are selective for translocator protein. TSPO ligand-1 has also been used in...
| Keywords: | Translocator Protein Ligand-1, alpha-oxo-2-phenyl-1H-indole-3-acetyl chloride |
| Application: | 2-phenylindolglyoxylamide derivative intermediate, TSPO binding |
| CAS | 4560-08-1 |
| MW: | 283.71 D |
From 64.00€
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Iproniazid
Item number: Cay45450-100
Iproniazid is an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 6.56 and 7.54 µM, respectively). It reduces immobility in an open swimming test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg. Iproniazid (300 and 400 mg/kg) induces acute hepatic necrosis in...
| Keywords: | 2-(1-methylethyl)hydrazide, 4-pyridinecarboxylic acid |
| Application: | MAO-A / MAO-B inhibitor |
| CAS | 54-92-2 |
| MW: | 179.22 D |
From 35.00€
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Proquazone
Item number: Cay45454-1
Proquazone is a non-steroidal anti-inflammatory drug (NSAID). It reduces carrageenan-induced edema in rats (ED50 = 5 mg/kg, p.o.) and bradykinin-induced bronchoconstriction in guinea pigs (ED50 = 0.01 mg/kg, i.v.). It also inhibits yeast-induced pyresis in rats. Formulations containing proquazone have been used in...
| Keywords: | RU 43-715, Sandoz-43-715, 7-methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone |
| Application: | NSAID |
| CAS | 22760-18-5 |
| MW: | 278.36 D |
From 140.00€
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Tracazolate
Item number: Cay45457-1
Tracazolate is a positive allosteric modulator of the GABAA receptor (GABAAR). It potentiates GABA-stimulated currents in X. laevis oocytes expressing alpha1beta3gamma2s and alpha1beta1delta subunit-containing GABAARs (EC50s = 1.5 and 16.7 µM, respectively) and increases the maximal response to GABA in X. laevis...
| Keywords: | ICI 136753, 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester |
| Application: | GABAA receptor positive allosteric modulator |
| CAS | 41094-88-6 |
| MW: | 304.39 D |
From 139.00€
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