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Sodium Chloride USP
Item number: S5000-01.1
Used to precipitate DNA. Also a component in bacterial, yeast and cell culture growth media. CAS No: 7647-14-5, Molecular Formula: NaCl, Molecular Weight: 58.44, Appearance: White crystalline or powder, Purity: 99.0-100.5%, Solubility (1M, 20°C): Colorless, clear, complete, Identification (USP): To Pass USP,...
| CAS | 7647-14-5 |
From 47.00€
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Taurine (2-Aminoethanesulfonic acid)
Item number: T1050.100
Taurine is an organic acid found in animal tissues and is a major constituent of bile. Taurine has many biological roles such as conjugation of bile acids, antioxidation, osmoregulation, membrane stabilization and modulation of calcium signaling. Taurine is a biological buffer (zwitterionic) designed by Good, et...
| CAS | 107-35-7 |
| MW: | 125.10 D |
231.00€
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Zotarolimus
Item number: Z0818.1
Zotarolimus (also known as ABT-578) is an analogue of rapamycin (sirolimus) that was designed to have a shorter in vivo half-life than rapamycin. Zotarolimus was found to be comparable in potency for inhibiting in vitro proliferation of both rat and human T cells and mechanistically similar to sirolimus in having...
| CAS | 221877-54-9 |
| MW: | 966.21 |
365.00€
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Sulindac
Item number: Cay10004386-1
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide, selective for COX-2 over COX-1 (IC50 = >1,000 µM), inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg, reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg....
| Keywords: | 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid |
| Application: | NSAID, COX-2 inhibitor |
| CAS | 38194-50-2 |
| MW: | 356.4 D |
From 23.00€
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Omidenepag (free acid)
Item number: Cay41045-1
A non-prostaglandin EP2 receptor agonist, selectively binds to human EP2 over EP1, EP3, and EP4 receptors (IC50s = 10, >10,000, >10,000, and 5,480 nM, respectively), induces cAMP accumulation in HEK293 cells expressing human EP2 receptors (EC50 = 1.1 nM). Formulation: A solid. InChI:...
| Keywords: | UR-7276, N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]-2-pyridinyl]-glycine |
| Application: | Non-prostaglandin EP2 receptor agonist |
| CAS | 1187451-41-7 |
| MW: | 478.5 D |
From 40.00€
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Omidenepag Isopropyl
Item number: Cay41046-1
A prodrug form of omidenepag, reduces IOP in ocular normotensive and laser-induced ocular hypertensive cynomolgus monkeys when topically administered at 0.01%/eye. Formulation: A solid. InChI:...
| Keywords: | DE 117, OMDI, N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-sulfonyl)amino]methyl]-2-pyridinyl]-glycine, 1-methylethyl ester |
| Application: | Omidenepag prodrug form |
| CAS | 1187451-19-9 |
| MW: | 520.6 D |
From 74.00€
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UNC-CA2-103
Item number: Cay41241-1
A TLK2 inhibitor (IC50 = 18 nM), selective for TLK2 over TLK1, TrkC, and FLT3 at 500 nM and a panel of 468 kinases at 1 µM, but it does inhibit 11 kinases by >90% in the same panel. Formulation: A solid. InChI:...
| Keywords: | Inhibitor 128, (Z)-N-(3-((4-methyl-1H-imidazol-5-yl)methylene)-2-oxoindolin-5-yl)benzamide |
| Application: | TLK2 inhibitor |
| MW: | 344.37 D |
From 40.00€
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Endosidin 5
Item number: Cay41328-1
An inhibitor of endosomal recycling and dCTPase 1 (IC50 = 1 µM), induces trafficking of endocytosed plasma membrane to the vacuole in Arabidopsis cells, inhibits the recycling of plasma membrane proteins in HeLa cells, inhibits annexin A6-mediated membrane remodeling in HEK293T cell lysates (EC50 = ~3 µM), enhances...
| Keywords: | ES5, 2-(3,7-dimethyl-2-quinolinyl)hydrazone 1H-indole-3-carboxaldehyde |
| Application: | Endosomal recycling / dCTPase 1 inhibitor |
| CAS | 364361-68-2 |
| MW: | 314.4 D |
From 122.00€
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Rupintrivir
Item number: Cay41543-1
An inhibitor of HRV 3C protease, inhibits HRV 3C protease-induced proteolysis of HRV-14 precursor polyproteins in HRV-14-infected H1HeLa cells at 2 µM, inhibits replication of 49 serotypes of HRV in HRV-infected H1HeLa cells (mean EC50 = 0.023 µM), inhibits replication of coxsackievirus 21, coxsackievirus B3,...
| Keywords: | AG-7088, Rupinavir,... |
| Application: | HRV 3C protease inhibitor |
| CAS | 223537-30-2 |
| MW: | 598.66 D |
From 116.00€
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JNJ-47117096 (trifluoroacetate salt)
Item number: Cay41605-1
A MELK inhibitor (IC50 = 37 nM), selective for MELK over CAMKIIdelta, MNK2, CAMKIIgamma, and MLCK (IC50s = 810, 760, 1,000, and 1,000 nM, respectively) but does inhibit FLT3 (IC50 = 18 nM), inhibits MELK autophosphorylation (IC50 = 0.52 µM) and MELK proteasome-dependent degradation in MCF-7 cells, induces cellular...
| Keywords: | 2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-benzamide, trifluoroacetate salt |
| Application: | MELK inhibitor |
| MW: | 476.4 D |
From 74.00€
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Werner Syndrome RecQ Helicase-IN-4
Item number: Cay41679-10
An inhibitor of WRN (IC50 = 60 nM), selectively inhibits the growth of SW48 cells over DLD-1-WRN-KO cells (GI50s = 70 and >10,000 nM, respectively), reduces tumor volume in an SW48 mouse xenograft model at 240 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Werner Syndrome RecQ Helicase Inhibitor 4, WS RecQ Helicase Inhibitor 4, WS RecQ Helicase-IN-4,... |
| Application: | WRN inhibitor |
| CAS | 2869954-53-8 |
| MW: | 666.7 D |
From 610.00€
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Lucitanib
Item number: Cay41711-1
A dual inhibitor of VEGFR and FGFR, inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50s = 7, 25, and 10 nM, respectively) and FGFR1 and FGFR2 (IC50s = 17.5 and 82.5 nM, respectively), selective for VEGFR1-3 and FGFR1-2 over FGFR3 and FGFR4 (IC50s = 237.5 and >1,000 nM, respectively), as well c-Kit, PDGFRalpha, and PDGFRbeta...
| Keywords: | AL 3810, E-3810, 6-[[7-[(1-aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-1-naphthalenecarboxamide |
| Application: | VEGFR / FGFR dual inhibitor |
| CAS | 1058137-23-7 |
| MW: | 443.5 D |
From 40.00€
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