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MSD-M1PAM
Item number: Cay41358-1
A positive allosteric modulator of M1 mAChRs, enhances ACh-induced calcium production in a calcium mobilization assay from 0.1-10 µM, reverses scopolamine-induced deficits in freezing behavior in mice from 1-30 mg/kg, attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object...
| Keywords: | PQCA, 1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid |
| Application: | Muscarinic acetylcholine receptor M1 positive allosteric modulator |
| CAS | 1144504-35-7 |
| MW: | 388.4 D |
From 80.00€
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Dovitinib (lactate)
Item number: Cay41394-1
A multi-kinase inhibitor, inhibits FLT3, CSF1R, c-Kit, FGFR1, FGFR3, VEGFR1, -2, and -3, PDFGRalpha, and PDGFRbeta (IC50s = 1, 36, 2, 8, 9, 10, 13, 8, 27, and 210 nM, respectively), inhibits the proliferation of human multiple myeloma cell lines expressing mutant, but not wild-type, FGFR3 (IC50s = 90-550 and >2,500...
| Keywords: | CHIR258, TKI-258, 2-hydroxy-propanoic acid, compd. with... |
| Application: | Multi-kinase inhibitor |
| CAS | 852433-84-2 |
| MW: | 572.59 D |
From 45.00€
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ML-401
Item number: Cay41450-10
An EBI2 antagonist (IC50 = 1.03 nM), inhibits RS11846 cell chemotaxis (IC50 = 4.533 nM). Formulation: A solid. InChI: InChI=1S/C20H20BrClN2O/c21-18-6-1-16(2-7-18)5-10-20(25)24-13-11-23(12-14-24)15-17-3-8-19(22)9-4-17/h1-10H,11-15H2/b10-5+. InChIKey: NXTNVQJKGHAGAX-BJMVGYQFSA-N. SMILES:...
| Keywords: | (2E)-3-(4-bromophenyl)-1-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-propen-1-one |
| Application: | EBI2 antagonist |
| CAS | 1597489-14-9 |
| MW: | 419.74 D |
From 116.00€
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Isoleucine
Item number: Cay41562-50
A mixture of isoleucine diastereomers. Formulation: A solid. InChI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9). InChIKey: AGPKZVBTJJNPAG-UHFFFAOYSA-N. SMILES: CCC(C)C(N)C(O)=O
| Keywords: | 2-amino-3-methyl-pentanoic acid |
| Application: | Isoleucine diastereomer mixture |
| CAS | 2095501-92-9 |
| MW: | 131.2 D |
55.00€
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DC-U4106
Item number: Cay41723-1
A USP8 inhibitor (IC50 = 1.2 µM), selective for USP8 over USP2 and USP7 (IC50s = 58.4 and >100 µM, respectively), induces apoptosis in, and inhibits colony formation by, MCF-7 cells from 1-5 µM, reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg. Formulation: A solid. InChI:...
| Keywords: | 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-4H-1-benzopyran-4-one |
| Application: | USP8 inhibitor |
| CAS | 2410534-62-0 |
| MW: | 525.6 D |
From 223.00€
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Spongosine
Item number: Cay41832-1
A nucleoside with diverse biological activities, antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors), inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM, decreases...
| Keywords: | 2-Methoxyadenosine, NSC 36899, 2-methoxy-adenosine |
| Application: | Bioactive nucleoside |
| CAS | 24723-77-1 |
| MW: | 297.3 D |
From 76.00€
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MMV390048
Item number: Cay41835-10
A P. vivax PI4K inhibitor (IC50 = 3.4 nM), active against P. falciparum (IC50 = 28 nM), decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg), reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys at 20...
| Keywords: | 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
| Application: | Plasmodium vivax PI4K inhibitor |
| CAS | 1314883-11-8 |
| MW: | 393.4 D |
From 107.00€
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AQW-051
Item number: Cay41851-10
A partial agonist of the alpha7 nAChR, induces calcium influx in GH3 cells expressing alpha7 nAChR (EC50 = 38.9 nM), improves learning and memory in the social recognition test in mice at 0.03 or 0.3 mg/kg, improves learning and memory in the Morris water maze test in rats at 3 mg/kg, increases the duration of...
| Keywords: | VQW-765, (3R)-3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-1-azabicyclo[2.2.2]octane |
| Application: | alpha7 nAChR partial agonist |
| CAS | 669770-29-0 |
| MW: | 294.4 D |
From 104.00€
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GSK3685032
Item number: Cay41882-1
A DNMT1 inhibitor (IC50 = 0.23 µM), selective for DNMT1 over DNMT3A/3L and DNMT3B/3L and a panel of 34 methyltransferases and 369 kinases (IC50s = >10 µM for all), inhibits the proliferation of 51 hematological cancer cell lines (median IC50 = 0.64 µM), decreases overall DNA methylation and gene expression in...
| Keywords: | aR-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-benzeneacetamide |
| Application: | DNMT1 inhibitor |
| CAS | 2170140-50-6 |
| MW: | 420.54 D |
From 104.00€
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Santalol
Item number: Cay41891-100
A mixture of alpha-santalol and beta-santalol. Formulation: A neat oil. InChI: InChI=1S/2C15H24O/c1-10(9-16)5-4-6-14(2)11-7-12-13(8-11)15(12,14)3,1-11(10-16)5-4-8-15(3)12(2)13-6-7-14(15)9-13/h5,11-13,16H,4,6-9H2,1-3H3,5,13-14,16H,2,4,6-10H2,1,3H3/b10-5-,11-5-/t11?,12-,13?,14+,15?,13-,14+,15+/m01/s1. InChIKey:...
| Application: | Sesquiterpenoids, alpha-santalol/beta-santalol mixture |
| CAS | 11031-45-1 |
| MW: | 220.4 D |
From 45.00€
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BH400
Item number: Cay41892-1
A PPARalpha agonist and STING inhibitor (IC50 = 8.1 µM), induces transactivation of PPARalpha in a reporter assay using THP-1 cells (EC50 = 1.2 µM), inhibits 4-HNE- or H2O2-induced decreases in viability in 661W cells at 10 µM, prevents LPS-induced increases in phosphorylated TBK1 and IL-6 levels and LPS-induced...
| Keywords: | 5-(((4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)amino)-2-hydroxybenzoic acid |
| Application: | PPARalpha agonist, STING inhibitor |
| MW: | 337.4 D |
From 116.00€
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DBCO acid
Item number: Cay41894-1
A copper-free click chemistry reagent, has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro, has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to...
| Keywords: | Dibenzocyclooctyne Acid, 11,12-didehydro-?-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid |
| Application: | Copper-free click chemistry reagent |
| CAS | 1353016-70-2 |
| MW: | 305.33 D |
From 43.00€
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