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![2-Amino-9H-pyrido[2,3-b]indole](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg "2-Amino-9H-pyrido[2,3-b]indole")
2-Amino-9H-pyrido[2,3-b]indole
Item number: Cay42114-10
A mutagenic heterocyclic amine, has been found in cooked foods, mutagenic to S. typhimurium in the Ames test and induces SCEs in NL3 cells, induces hepatic and blood vessel tumor formation in mice at 0.08% in the diet, has been found in the urine of cigarette smokers. Formulation: A solid. InChI:...
| Keywords: | 2-Amino-alpha-Carboline, AalphaC, 9H-pyrido[2,3-b]indol-2-amine |
| Application: | Mutagenic heterocyclic amine |
| CAS | 26148-68-5 |
| MW: | 183.2 D |
From 122.00€
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Dendrophenol
Item number: Cay42115-1
A polyphenol with diverse biological activities, decreases viability of, and induces cell cycle arrest at the S phase in, HCT116 cells at 10 µM, inhibits the migration of MDA-MB-231 cells at 3 or 10 µM, inhibits LPS-induced increases in iNOS, COX-2, HIF-1alpha, and NF-kappaB levels and NF-kappaB nuclear...
| Keywords: | Aloifol II, Moscatilin, 4-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2,6-dimethoxy-phenol |
| Application: | Bioactive polyphenol |
| CAS | 108853-14-1 |
| MW: | 304.3 D |
From 101.00€
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K114
Item number: Cay34218-1
A fluorescent probe for the detection of amyloids, pH-dependent ex/em maxima = 370/450 nm, respectively, at pH 8.5, pH-dependent ex/em maxima = 420/520 nm, respectively, at pH 10.5, demonstrates increased fluorescence intensity in the presence of Aß40 fibrils, displays fiber-dependent excitation/emission maxima for...
| Keywords: | 4,4'-[(2-bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-phenol |
| Application: | Fluorescent amyloid detection probe |
| CAS | 872201-12-2 |
| MW: | 393.27 D |
From 40.00€
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I-OMe AG-538
Item number: Cay35090-1
An IGF-1R and PI5P4Ka inhibitor (IC50s = 3.4 and 1 µM, respectively), selectively cytotoxic to nutrient-deprived PANC-1 cells over nutrient-sufficient PANC-1 cells. Formulation: A solid. InChI: InChI=1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+....
| Keywords: | I-OMe Tyrphostin AG-538, 3,4-dihydroxy-aE-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]-beta-oxo-benzenepropanenitrile |
| Application: | IGF-1R / PI5P4Ka inhibitor |
| CAS | 1094048-77-7 |
| MW: | 437.2 D |
From 45.00€
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Doxycycline (hydrate)
Item number: Cay35830-1
A broad-spectrum tetracycline antibiotic, inhibits bacterial protein synthesis, selectively inhibits human MMP-8 and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, at 30 µM, can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or...
| Keywords: | (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-... |
| Application: | Broad-spectrum tetracycline antibiotic |
| CAS | 17086-28-1 |
| MW: | 462.45 D |
From 40.00€
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LNP GalNAc Ligand 1 (trifluoroacetate salt)
Item number: Cay38952-1
An ASGPR-targeting ligand, has been used in the formation of LNPs for the hepatic delivery of CRISPR base editors in mice. Formulation: A solid. InChI:...
| Keywords: | Lipid Nanoparticle GalNAc Ligand 1, Lipid Nanoparticle N-Acetylgalactosamine Ligand 1, LNP N-Acetylgalactosamine Ligand 1,... |
| Application: | ASGPR-targeting ligand |
| CAS | 1159408-65-7 |
| MW: | 1908 D |
From 70.00€
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Lirafugratinib
Item number: Cay40940-1
A covalent FGFR2 inhibitor (IC50 = 0.003 µM), selective for FGFR2 over FGFR1, -3, and -4 (IC50s = 0.77, 0.26, and 15 µM, respectively), inhibits the proliferation of SNU-16 cells (IC50 = 0.002 µM), reduces intratumoral FGFR2 phosphorylation and tumor volume in an FGFR2-amplified SNU-16 gastric cancer mouse xenograft...
| Keywords: | RLY-4008,... |
| Application: | Covalent FGFR2 inhibitor |
| CAS | 2549174-42-5 |
| MW: | 509.5 D |
From 55.00€
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LGD 6972 (ammonium salt)
Item number: Cay40961-1
A GCGR antagonist, reduces glucagon-induced hyperglycemia in wild-type mice, reduces blood glucose levels in mouse models of diabetes. Formulation: A solid. InChI:...
| Keywords: | 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]b... |
| Application: | GCGR antagonist |
| MW: | 719.9 D |
From 74.00€
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CVN293
Item number: Cay40983-1
A K2P13.1/THIK1 channel inhibitor (IC50 = 49 nM), selective for K2P13.1/THIK1 over K2P6.1/TWIK2 and K2P2.1/TREK-1 channels (IC50s = >30,000 nM for both), inhibits NLRP3 inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia (IC50 = 24 nM). Formulation: A solid. InChI:...
| Keywords: | 4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine |
| Application: | K2P13.1/THIK1 channel inhibitor |
| CAS | 2815296-08-1 |
| MW: | 311.27 D |
From 105.00€
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ECC5004
Item number: Cay41324-1
A GLP-1R agonist, induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = <20 nM). Formulation: A solid. InChI:...
| Keywords: | AZD 5004,... |
| Application: | GLP-1R agonist |
| CAS | 3011682-51-9 |
| MW: | 880.94 D |
299.00€
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VPS34-IN-19
Item number: Cay41357-10
An inhibitor of VPS34 (IC50 = 15 nM), selective for VPS34 over PI3Kdelta (IC50 = 802 nM) and PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >802 nM for all), increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per...
| Keywords: | Compound 19, Vacuolar Protein Sorting 34 Inhibitor 19, VPS Inhibitor 19,... |
| Application: | VPS34 inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.5 D |
From 147.00€
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MSD-M1PAM
Item number: Cay41358-1
A positive allosteric modulator of M1 mAChRs, enhances ACh-induced calcium production in a calcium mobilization assay from 0.1-10 µM, reverses scopolamine-induced deficits in freezing behavior in mice from 1-30 mg/kg, attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object...
| Keywords: | PQCA, 1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid |
| Application: | Muscarinic acetylcholine receptor M1 positive allosteric modulator |
| CAS | 1144504-35-7 |
| MW: | 388.4 D |
From 80.00€
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