Dendrophenol

A polyphenol with diverse biological activities, decreases viability of, and induces cell cycle arrest at the S phase in, HCT116 cells at 10 µM, inhibits the migration of MDA-MB-231 cells at 3 or 10 µM, inhibits LPS-induced increases in iNOS, COX-2, HIF-1alpha, and NF-kappaB levels and NF-kappaB nuclear translocation in RAW 264.7 macrophages at 100 µM, reduces tumor size without affecting body weight in an HCT116 mouse xenograft model at 50 or 100 mg/kg per day, decreases total lung weight in an MDA-MB-231 mouse xenograft model at 100 mg/kg per day. Formulation: A solid. InChI: InChI=1S/C17H20O5/c1-20-14-8-11(6-7-13(14)18)4-5-12-9-15(21-2)17(19)16(10-12)22-3/h6-10,18-19H,4-5H2,1-3H3. InChIKey: YTRAYUIKLRABOQ-UHFFFAOYSA-N. SMILES: COC1=CC(CCC2=CC=C(O)C(OC)=C2)=CC(OC)=C1O