8-Cyclopentyl-1,3-dimethylxanthine

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is an adenosine A1 receptor antagonist (Ki = 10.9 nM). It is selective for adenosine A1 over A2 receptors (Ki = 1,440 nM). CPT inhibits hypoxia-induced depression of evoked synaptic potentials in rat hippocampal slices in a concentration-dependent manner. It increases secondary after-discharge duration in electrically induced seizures in rats when administered at doses of 2.5 mg/kg or higher. CPT increases the response rate under a fixed-interval schedule of stimulus-shock termination in squirrel monkeys (ED50 = 2.5 µmol/kg), indicating psychomotor stimulant effects.Formal Name: 8-cyclopentyl-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione. CAS Number: 35873-49-5. Synonyms: CPT, 8-Cyclopentyltheophylline, NSC 101806. Molecular Formula: C12H16N4O2. Formula Weight: 248.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml. lambdamax: 275 nm. SMILES: CN1C(N(C)C(N=C(C2CCCC2)N3)=C3C1=O)=O. InChi Code: InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14). InChi Key: SCVHFRLUNIOSGI-UHFFFAOYSA-N.